Tag Archives: Jean-Laurent Casanova

In the News – Newsweek – Casanova

To fight superbugs, scientists are turning toward antibodies   “‘The bottom line is that the bacteria now develop resistance to anti-infectious agents faster than we can develop the anti-infectious agents,’ says Dr. Jean-Laurent Casanova, a professor at Rockefeller University who … More »

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Jean-Laurent Casanova honored with the Korsmeyer Award

Jean-Laurent Casanova honored with the Korsmeyer AwardJean-Laurent Casanova is the recipient of the 2016 Stanley J. Korsmeyer Award. The award recognizes Casanova for discovering that vulnerability to life-threatening infectious illnesses in otherwise healthy children and young adults can arise from single-gene inborn errors. More »

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Researchers develop gene-filtering tool to identify disease-causing mutations

Genes that are frequently mutated in the general population are unlikely to cause disease, because variations of these genes are often found in healthy people. A new tool from researchers at Rockefeller uses this concept to help scientists identify the mutations in genes that matter. More »

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Jean-Laurent Casanova elected to the National Academy of Medicine

Jean-Laurent Casanova elected to the National Academy of MedicineWith his election, Casanova, who investigates the genetic underpinnings of unusual vulnerability to specific infectious diseases among young people, receives one of the highest honors within the field of medicine. Seventeen Rockefeller scientists are currently members of the academy of medicine. More »

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Mutations in a single gene underlie vulnerability to two unrelated types of infections

Mutations in a single gene underlie vulnerability to two unrelated types of infectionsResearchers have identified a surprising case in which defects in a single immune gene render children susceptible to two very different diseases: aggravating, but treatable fungal infections, as well as invasive and potentially fatal bacterial disease. This finding suggests a dual role for that gene, RORC, in human immunity to infection. More »

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Leslie Vosshall and Jean-Laurent Casanova elected to the National Academy of Sciences

Jean-Laurent Casanova and Leslie Vosshall elected to the National Academy of Sciences

Vosshall, who investigates how sensory stimuli are perceived and processed, and Casanova, who studies the genetics of infectious disease susceptibility in children, are among the new members and foreign associates to be inducted into the Academy in 2015. With Vosshall and Casanova’s election, Rockefeller now boasts 36 members or foreign associates of the National Academy of Sciences among its current faculty.

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In the News – NPR – Casanova

A single gene may determine why some people get so sick with the flu “The study helps explain genetic variation changes the way that people fight off viruses. ‘The response to influenza is genetically impaired,’ says [Jean-Laurent] Casanova. He’s hoping … More »

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Genetic mutation helps explain why, in rare cases, flu can kill

Genetic mutation helps explain why, in rare cases, flu can killA small number of children who catch the influenza virus fall so ill they end up in the hospital even while their family and friends recover easily. New research from Rockefeller helps explain why: a rare genetic mutation that prevents the production of a critical protein, interferon, that is needed to fight off the virus. More »

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Key to blocking influenza virus may lie in a cell’s own machinery

Key to blocking influenza virus may lie in a cell’s own machineryResearchers have found that the immune system fights a flu infection by turning off cellular enzymes the virus needs to put the final touches on new viral particles. The unfinished particles cannot spread infection to new cells. More »

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Single gene links susceptibility to rare infections with predisposition to autoimmune disease

Single gene links susceptibility to rare infections with predisposition to autoimmune diseaseWhen scientists scanned the brains of patients who lack a particular immune protein, they saw calcium deposits linked with certain diseases that occur as a result of harmful and unnecessary inflammation. More »

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Jean-Laurent Casanova to receive 2014 Robert Koch Award

Jean-Laurent Casanova to receive 2014 Robert Koch Award Casanova is honored for his work on host genes and their products in infectious diseases. His lab is interested in why some children develop severe infectious diseases after coming into contact with certain pathogens, while most other children do not. More »

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A new web tool effectively prioritizes disease-causing genes by biological distance

With the Human Gene Connectome, an investigator can rank potential disease-causing genes based on a new metric called biological distance. This tool is now available online thanks in part to the work of two high school students. More »

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Jean-Laurent Casanova appointed HHMI investigator

Casanova, whose research established for the first time that a predisposition to infectious diseases in children can be genetically determined, has been named one of 27 new investigators with the Howard Hughes Medical Institute. His appointment brings the total number of Rockefeller scientists supported by HHMI to 16. More »

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Scientists discover gene mutation that causes children to be born without spleen


An international team of scientists led by Rockefeller University researchers has identified the defective gene responsible for a rare disorder in which children are born without a spleen, which makes them susceptible to life-threatening bacterial infections early in life. The findings may lead to new diagnostic tests and raises new questions about the role of this gene in the body’s protein-making machinery.

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Researchers create map of “shortcuts” between all human genes

Researchers at Rockefeller University, along with colleagues at Necker Hospital for Sick Children and the Pasteur Institute in Paris and Ben-Gurion University in Israel, have generated the full set of distances, routes and degrees of separation between any two human genes, creating a map of gene “shortcuts” that aims to simplify the hunt for disease-causing genes in monogenic diseases. More »

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Brain displays an intrinsic mechanism for fighting infection

Researchers in the St. Giles Laboratory of Human Genetics of Infectious Diseases have shed light on how a genetic defect leaves some children susceptible to a rare and damaging brain infection and have found evidence of an intrinsic immune mechanism in the brain that fights the viral infection in healthy people. More »

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Protein proves vital in immune response to bacteria

Research led by Rockefeller University scientists found that a protein once thought to be mainly involved in antiviral immunity is instead vital to fighting a type of bacteria that cause diseases such as tuberculosis and leprosy.
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Jean-Laurent Casanova to receive 2012 Milstein Award

The award is bestowed upon a leading biomedical research scientist who has made outstanding contributions to interferon and cytokine research, either in a basic or applied field. Casanova’s studies have important clinical implications, as they provide a rationale for developing new therapeutic approaches based on an understanding of the host component of infectious diseases. More »

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Jean-Laurent Casanova honored with Belgium’s highest scientific prize

Jean-Laurent Casanova has received the 2011 InBev-Baillet Latour Health Prize, Belgium’s most important scientific prize, for his pioneering work on the identification of genes that predispose for human infectious disease. More »

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Rockefeller immunologist receives Gates Foundation Grand Challenges grant

Jean-Laurent Casanova will launch a new project aimed at understanding how a collection of genetically diverse errors in immunity leads to susceptibility to tuberculosis in children under 15 years old. More »

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