Tag Archives: Jean-Laurent Casanova
Researchers have identified a surprising case in which defects in a single immune gene render children susceptible to two very different diseases: aggravating, but treatable fungal infections, as well as invasive and potentially fatal bacterial disease. This finding suggests a dual role for that gene, RORC, in human immunity to infection. More »
Vosshall, who investigates how sensory stimuli are perceived and processed, and Casanova, who studies the genetics of infectious disease susceptibility in children, are among the new members and foreign associates to be inducted into the Academy in 2015. With Vosshall and Casanova’s election, Rockefeller now boasts 36 members or foreign associates of the National Academy of Sciences among its current faculty.
A single gene may determine why some people get so sick with the flu “The study helps explain genetic variation changes the way that people fight off viruses. ‘The response to influenza is genetically impaired,’ says [Jean-Laurent] Casanova. He’s hoping … More »
A small number of children who catch the influenza virus fall so ill they end up in the hospital even while their family and friends recover easily. New research from Rockefeller helps explain why: a rare genetic mutation that prevents the production of a critical protein, interferon, that is needed to fight off the virus. More »
When scientists scanned the brains of patients who lack a particular immune protein, they saw calcium deposits linked with certain diseases that occur as a result of harmful and unnecessary inflammation. More »
Casanova is honored for his work on host genes and their products in infectious diseases. His lab is interested in why some children develop severe infectious diseases after coming into contact with certain pathogens, while most other children do not. More »
With the Human Gene Connectome, an investigator can rank potential disease-causing genes based on a new metric called biological distance. This tool is now available online thanks in part to the work of two high school students. More »
Casanova, whose research established for the first time that a predisposition to infectious diseases in children can be genetically determined, has been named one of 27 new investigators with the Howard Hughes Medical Institute. His appointment brings the total number of Rockefeller scientists supported by HHMI to 16. More »
An international team of scientists led by Rockefeller University researchers has identified the defective gene responsible for a rare disorder in which children are born without a spleen, which makes them susceptible to life-threatening bacterial infections early in life. The findings may lead to new diagnostic tests and raises new questions about the role of this gene in the body’s protein-making machinery.
Researchers at Rockefeller University, along with colleagues at Necker Hospital for Sick Children and the Pasteur Institute in Paris and Ben-Gurion University in Israel, have generated the full set of distances, routes and degrees of separation between any two human genes, creating a map of gene “shortcuts” that aims to simplify the hunt for disease-causing genes in monogenic diseases. More »
Research led by Rockefeller University scientists found that a protein once thought to be mainly involved in antiviral immunity is instead vital to fighting a type of bacteria that cause diseases such as tuberculosis and leprosy.
The award is bestowed upon a leading biomedical research scientist who has made outstanding contributions to interferon and cytokine research, either in a basic or applied field. Casanova’s studies have important clinical implications, as they provide a rationale for developing new therapeutic approaches based on an understanding of the host component of infectious diseases. More »
Jean-Laurent Casanova has received the 2011 InBev-Baillet Latour Health Prize, Belgium’s most important scientific prize, for his pioneering work on the identification of genes that predispose for human infectious disease. More »
Jean-Laurent Casanova will launch a new project aimed at understanding how a collection of genetically diverse errors in immunity leads to susceptibility to tuberculosis in children under 15 years old. More »
It turns out that the immune system can create its own infections. Scientists now report that the immune-fighting proteins that keep yeast in check in healthy immune systems are under siege in patients with a rare autoimmune disorder known as APS-1. By pinpointing the cause of candidiasis in these patients, the finding paves the way for treating these fungal infections with drugs that are already out in the market. More »
Everybody gets sick, but how sick you get is in your genes. New research now reveals a mutation on a gene that makes children susceptible to a severe form of mycobacterial disease. The work not only supports a controversial idea that certain genes evolved to combat specific bacteria but also reveals new mechanistic details of how the immune system fights off one of the planet’s fiercest pathogens. More »
Jean-Laurent Casanova, a distinguished pediatrician and immunologist who comes from Hospital Necker for Sick Children in Paris, will join the faculty at The Rockefeller University as professor of medicine and head of the Laboratory of Human Genetics of Infectious Diseases in September 2008. More »