Tag Archives: Jeffrey Ravetch

Jeffrey V. Ravetch receives 2017 Ross Prize in Molecular Medicine

Jeffrey V. Ravetch receives 2017 Ross Prize in Molecular MedicineRavetch, who studies the role of antibodies in the immune system, has won the 2017 Ross Prize in Molecular Medicine. Given by The Feinstein Institute for Medical Research and its journal Molecular Medicine, the award recognizes scientists who have made a significant impact on the understanding of human disease pathogenesis. More »

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Discovery helps explain why only some people develop life-threatening dengue infections

Discovery helps explain why only some people develop life-threatening dengue infectionsAfter contracting dengue fever once, certain people who encounter the virus again develop much more severe infections. New research identifies an immunological signature that could help identify and better treat these patients. More »

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New mouse models give a boost to the development of cancer immunotherapies

New mouse models give a boost to the development of cancer immunotherapiesA new cancer treatment called CD40 antibody has yielded disappointing results when tested in clinical trials, failing to mobilize patients’ immune system against tumors the way it was expected to. But a recent study offers clues about how this experimental drug might be optimized to fulfill its potential. More »

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Discovery points to a new path toward a universal flu vaccine

Discovery points to a new path toward a universal flu vaccineTaking advantage of a previously unknown mechanism within the immune system, researchers think they may be able to improve the immune response to the flu vaccine. If successful, this could mean less frequent flu shots that offer broad protection against the many strains of this ever-mutating virus. More »

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Research shows how antibodies produce vaccine-like effect against tumors

Research shows how antibodies produce vaccine-like effect against tumorsAntibody therapy not only kills cancerous cells, it can confer lasting protection by priming the immune system to remember a tumor. Scientists have found this process centers on antibody-binding receptors found on two types of immune cells. Their results suggest ways to improve anti-cancer treatments. More »

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Jeffrey Ravetch wins Wolf Prize in Medicine

Jeffrey Ravetch wins Wolf Prize in MedicineConsidered one of the most prestigious prizes in medicine, the Wolf Prize recognizes Ravetch’s work on the molecular basis of the immune response, including the Fc receptor system that mediates antibody function in disease and health. More »

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Antibodies, together with viral ‘inducers,’ found to control HIV in mice

Antibodies, together with viral ‘inducers,’ found to control HIV in miceA new strategy devised by researchers at Rockefeller University harnesses the power of broadly neutralizing antibodies, along with a combination of compounds that induce viral transcription, in order to attack latent reservoirs of HIV-infected cells in an approach termed ‘shock and kill.’ More »

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Jeffrey Ravetch wins 2012 Sanofi – Institut Pasteur Award

The award recognizes researchers for their past or ongoing studies advancing understanding of the life sciences, and Ravetch is being recognized for discovering mechanisms by which antibodies carry out their diverse biological functions. He is one of four scientists to be honored for research projects in tropical and neglected diseases, innovative vaccines, new approaches to drug resistance and therapeutic approaches to senescence. More »

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Jeffrey V. Ravetch and Michael W. Young to receive Canada Gairdner International Awards

The Gairdner Foundation is recognizing Jeffrey V. Ravetch for his work demonstrating how our immune system can be both protective and harmful and Michael W. Young for his nearly three decades of research on circadian rhythms, the biological clocks that regulate our bodies’ patterns of sleep and wakefulness, metabolism and response to disease. The Gairdner, which is Canada’s highest scientific award, is considered among the top ten most prestigious international prizes in science. The scientists will each receive $100,000 from the Gairdner Foundation.

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Research identifies cell-receptor as target for anti-inflammatory immune response

A common treatment for autoimmune diseases — intravenous immunoglobulin or IVIG — has defied scientific explanation for years. But researchers at The Rockefeller University have homed in on a specialized cell receptor in the immune system that facilitates IVIG’s work, suggesting a target for new potential anti-inflammatory agents. More »


A blood marker may indicate Alzheimer’s risk

In research that could lead to a simple test for certain forms of dementia, scientists have found that when blood levels of a specific protein decrease over time, the change could herald the onset of Alzheimer’s disease or other types of cognitive impairment. More »

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Jeffrey Ravetch elected to American Academy of Arts and Sciences

An immunologist who studies how cells respond to specific antibodies has been elected to The American Academy of Arts and Sciences, an independent policy research center that undertakes studies of complex and emerging problems. More »

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Newly refined antibody therapy may be potent treatment for autoimmune diseases

Despite its variable efficacy, IVIG — a therapeutic made from the pooled plasma of healthy blood donors — has been used for years. Now, researchers have reengineered it to create a therapy that could be far more effective. More »


Jeffrey Ravetch elected to Institute of Medicine

Jeffrey V. Ravetch, head of Rockefeller University’s Leonard Wagner Laboratory of Molecular Genetics and Immunology, is one of 65 new members and four foreign associates whose election to the Institute of Medicine was announced today. More »

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Removing a sugar turns protective antibodies into attackers

Antibodies associated with more destructive autoimmune diseases appear to be lacking a sialic acid sugar molecule at the stem of their Y-shaped structure. More »


Jeffrey Ravetch to receive William B. Coley Award

The Cancer Research Institute, which administers the annual prize to a scientist studying basic and tumor immunology, chose Ravetch for his work on Fc receptors, which has led to fundamental discoveries critical to the design of therapeutic antibodies. More »

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Scientists ID a single sugar that allows antibodies to fight inflammation

Rockefeller researchers have uncovered how a widely used yet little-understood therapy for autoimmune diseases like asthma and lupus works. The treatment, called IVIG, is effective because a small fraction of the antibodies it contains are affixed with a single sugar that gives the antibodies a protective, anti-inflammatory effect. And now that they understand how it works, they may be able to turn an adequate treatment into something that’s 100 times more effective and chemically pure. More »

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Four Rockefeller scientists elected to the National Academy of Sciences

Titia de Lange, Charles D. Gilbert, Michael E. O’Donnell and Jeffrey V. Ravetch, all heads of laboratories at Rockefeller University, have been elected to the U.S. National Academy of Sciences, a private organization of scientists and engineers dedicated to the furtherance of science and its use for the general welfare. More »

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Researchers uncover a pathway linked to autoimmune disease

In a series of discoveries that has the potential to help researchers halt autoimmune disorders — such as lupus and rheumatoid arthritis — a Rockefeller University scientist has found an underlying mechanism that begins to explain the pathologies of a number of immune diseases. More »

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Immune cell receptors act in combination to regulate attack

Not all antibodies are created equal, and Rockefeller researchers have just pinned down one reason why: Each one activates different combinations of receptors on an immune cell’s surface, and only one combination results in the most effective immune response. More »

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