Tag Archives: Laboratory of Biochemistry and Molecular Biology
The expression of about three-quarters of a cell’s active genes is controlled by a process in which the DNA-transcribing enzyme hesitates before going to work. Experiments have identified the complex of proteins that helps restart this enzyme when it stalls, and so helped to explain how some promising cancer drugs work. More »
In some cases of acute myeloid leukemia, a mutant protein is known to cause dramatic changes in gene expression. Now researchers have identified a second protein with similar function that plays an even broader role in the disease. More »
Marraffini, who studies the adaptive immune systems, known as CRISPR-Cas systems, found in some bacteria and used in genome editing, has won the Earl and Thressa Stadtman Scholar Award. Meanwhile, Robert Roeder, who investigates the mechanisms that regulate transcription, the process by which genes are copied into RNA, is the recipient of the Herbert Tabor Research Award.
Praised as “towering figures” in cell research, the scientists are being recognized for helping to define how cells grow, replicate, and become specialized, and in turn giving medical professionals and researchers the tools to improve health and combat diseases. James E. Darnell Jr., head of the Laboratory of Molecular Cell Biology, and Robert G. Roeder, head of the Laboratory of Biochemistry and Molecular Biology, will share the $500,000 prize from the 12th annual award, given at a May 11 ceremony in Albany, NY.
Robert G. Roeder, head of the Laboratory of Biochemistry and Molecular Biology, will receive the Salk Institute’s Medal for Research Excellence for his contributions to the understanding of RNA synthesis in animal cells. More »
In muscle, a protein called MED1 normally suppresses a genetic program that holds in check certain energy expenditure pathways. But when Rockefeller University scientists removed this gene in mice, a number of genes that are usually suppressed were activated, suggesting that targeting the Med1 gene could provide new therapeutical approaches to treating such metabolic diseases as obesity and diabetes. More »