Tag Archives: Laboratory of Brain Development and Repair
A physician-scientist widely recognized for uncovering the underlying causes of hypertension and other diseases, Lifton takes office on September 1. He replaces Marc Tessier-Lavigne, who left to lead Stanford University. More »
Using an approach that makes brain tissue transparent, researchers were able to view clumps of the toxic protein amyloid-β from multiple angles within mouse and human brains. More »
With a new imaging tool, scientists are able to measure the activity of all the neurons in a mouse brain with unmatched precision. The method is widely applicable for studying how the brain functions both under normal conditions and in disease. More »
Scientists solve CRISPR’s ‘Energizer Bunny’ problem “‘It works beautifully,’ Tessier-Lavigne said. With standard CRISPR-Cas9, 6 percent to 35 percent of the edits were clean, without random insertions and deletions due to Cas9’s repeated cuts, but with their upgrade, the … More »
Scientists have long believed axons regulate their own pruning during development. But recent findings have challenged this assumption, and now scientists have proven that axons receive instructions from the cell body when its time to degenerate.
In the developing nervous system, some neurons must extend their branches to connect one half of the brain with the other. A new study sheds light on the molecular mechanisms that guide the winding paths of their axons. More »
Experiments show that a protein already implicated in degeneration, called Sarm1, functions to trigger the MAP kinase pathway. Inactivation of this pathway at any of three levels could block the death of damaged axons.
In a significant technical advance, a team of neuroscientists at The Rockefeller University has devised a fast, inexpensive imaging method for probing the molecular intricacies of large biological samples in three dimensions, an achievement that could have far reaching implications in a wide array of basic biological investigations. More »
Marc Tessier-Lavigne, a leading neuroscientist and the former chief scientific officer of Genentech, takes over as president of The Rockefeller University today, replacing Paul Nurse, who has left to become president of the Royal Society in London. More »