Tag Archives: Laboratory of Mass Spectrometry and Gaseous Ion Chemistry

Researchers shed new light on RNA’s journey out of a cell’s nucleus

Researchers shed new light on RNA’s journey out of a cell’s nucleusTo make proteins, cells must export RNA from their carefully guarded nuclei. Researchers have determined the structure of one important component of the restrictive gate through which this cargo must pass, with implications for understanding disease. More »

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Parasites reveal how evolution has molded an ancient nuclear structure

Parasites reveal how evolution has molded an ancient nuclear structureThe architecture of the nuclear pore complex is similar in humans and yeast, suggesting that it had been established over a billion years ago. But new research in a simple parasite, the trypanosome, indicates that it has actually been evolving steadily. More »

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New technique efficiently turns antibodies into highly tuned ‘nanobodies’

New technique efficiently turns antibodies into highly tuned ‘nanobodies’Antibodies’ tiny cousins have many potential uses, but scientists haven’t been able to take advantage of them. However, a new technique may make nanobodies dramatically more accessible for all kinds of research. More »

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Bacterial protein mimics its host to disable a key enzyme

Bacteria use all sorts of cunning to trick hosts into doing their bidding. One con in their bag of tricks: the molecular mimic. In this ruse, bacteria or their agents look for all purposes like some native molecule in a cell, but then do not behave accordingly. Working with H. pylori, the bacterium responsible for gastric ulcers and cancer, researchers have revealed one way bacteria pull this off, deciphering the structure of a piece of CagA, a bacterial protein that impersonates a human protein in order to disable a key enzyme. More »

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New molecule identified in DNA damage response

Evolution places the highest premium on reproduction, natural selection’s only standard for biological success. In the case of replicating cells, life spares no expense to ensure that the offspring is a faithful copy of the parent. Researchers have identified a new player in this elaborate system of quality control, a gene whose mutation can cause a rare but lethal disease. More »

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