Tag Archives: Laboratory of Molecular Immunology

Early intervention with new treatment provides durable control of HIV-like virus in monkeys

Early intervention with new treatment provides durable control of HIV-like virus in monkeysResearchers have found that a new approach to HIV treatment can suppress an HIV-like virus for an extended period in monkeys. The therapy employs antibodies and takes advantage of the immune system’s natural defenses. More »

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Encouraging clinical results for an antibody drug to prevent or treat HIV

Encouraging results for an antibody drug to prevent or treat HIVA drug known as 10-1074, based on a human antibody against HIV, has dramatically reduced virus levels in patients and appeared to prevent infection among those at high risk, according to data from a new clinical trial. More »

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Michel C. Nussenzweig honored with the 2016 Robert Koch Award

Michel C. Nussenzweig honored with the 2016 Robert Koch AwardGiven by the Robert Koch Foundation, the annual award is one of Germany’s most prestigious scientific prizes, honoring extraordinary accomplishments in infectious disease research. Nussenzweig will share the €100,000 prize with Alberto Mantovani of Humanitas University for their achievements in immunology. More »

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Two Rockefeller postdocs recognized by Blavatnik Regional Awards

Two Rockefeller postdocs recognized by Blavatnik Regional Awards

Hani Goodarzi and Ziv Shulman have been named a winner and a finalist, respectively, by the Blavatnik Regional Awards, which honor outstanding postdoctoral scientists in New York, New Jersey, and Connecticut. Goodarzi is a postdoc in Sohail Tavazoie’s lab; Shulman, a former postdoc in Michel Nussenzweig’s lab, has since established his own lab at the Weizmann Institute of Science in Israel.

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Cell division speeds up as part of antibody selection, study shows

Cell division speeds up as part of antibody selection, study showsIn response to an infection, the immune system refines its defensive proteins, called antibodies, to better target the invader. New research has revealed two mechanisms that favor the selection of B cells capable of producing antibodies finely tuned to target that invader. More »

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Sequential immunizations could be the key to HIV vaccine

Sequential immunizations could be the key to HIV vaccineScientists have thought for some time that multiple immunizations, each tailored to specific stages of the immune response, could be used to generate a special class of HIV-fighting antibodies, so-called broadly neutralizing antibodies. These findings provide the first evidence supporting this approach. More »

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Latent HIV may lurk in ‘quiet’ immune cells, research suggests

Latent HIV may lurk in ‘quiet’ immune cells, research suggestsWhen researchers sequenced and compared sites where the virus had integrated into the genomes of infected CD4 T cells, they found evidence dormant but dangerous HIV was hiding out in cells that had never been copied – not the more abundant cloned cells. More »

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Imaging studies open a window on how effective antibodies are formed

Imaging studies open a window on how effective antibodies are formedBy imaging the immune response, researchers have observed how two types of immune cells interact with one another during a critical period following infection in order to prepare the best antibodies and establish long-lasting protection. More »

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Research on killer HIV antibodies provides promising new ideas for vaccine design

By detailing the molecular workings of broadly neutralizing anti-HIV antibodies, found in so-called slow-progressing HIV patients, researchers hope to devise a way to arm those who are not equipped with exceptional immunological firepower. New clues reveal that some anti-HIV antibodies are especially sticky and target a previously unrecognized part of the virus. More »

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Researchers modify yellow fever vaccine to fight malaria

A genetically modified vaccine originally used to eradicate yellow fever could be the key to stopping a mosquito-borne scourge that afflicts much of the developing world. More »

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