Tag Archives: Luciano Marraffini
Marraffini, who studies the CRISPR-Cas systems that enable some bacteria to acquire immunity against viruses, is among 32 highly qualified young faculty researchers selected to compete for this national award. More »
For years, researchers have puzzled over conflicting results about the workings of type III CRISPR-Cas systems, a type of immune system found in many species of bacteria. Some data showed that this mechanism would target the virus’s DNA, while other experiments suggested it could only disable a virus once it had started replicating itself. New results suggest both mechanisms play a role.
The enzyme Cas9 is well known for its ability to make precise cuts in a genome. New research reveals a new role for Cas9 in its native bacteria: helping the microbial immune system acquire a memory of an invading virus. More »
By co-opting a system bacteria normally use to defend themselves, researchers targeted and killed off colonies of the antibiotic resistant Staph cells on mouse skin. The treatment left behind the drug-susceptible microbes. More »
Viruses can kill bacteria, or viruses can help the microbes by lending them potentially useful genes. New research shows Staph bacteria have an immune system capable of distinguishing dangerous invaders from potentially beneficial ones. More »
Two Rockefeller University faculty have been awarded the NIH Director’s Transformative Award and three are being given New Innovator Awards.
Experiments in pneumococcal bacteria show how an RNA interference mechanism known as CRISPR can be used to prevent the uptake of genetic material from the environment. Harnessing this mechanism could be a new way to manipulate bacterial evolution in ways that might be medically useful. More »
Rockefeller’s newest faculty member is Luciano Marraffini, a microbiologist who studies how bacterial pathogens modulate the transfer of foreign DNA into their genomes. His work sheds light on how bacteria such as Staphylococcus aureus evolve, including how they gain the ability to resist antibiotic drugs. More »