Tag Archives: Luciano Marraffini
Researchers have identified a mutation that prompts bacterial cells to acquire genetic memories 100 times more frequently than they do naturally. This discovery provides a powerful research tool and could bring scientists one step closer to developing DNA-based data storage devices. More »
Like humans, bacteria come under attack from viruses—and their immune systems, like ours, are capable of remembering a virus so as to preempt any future invasion. New research explores how the bacterial immune system CRISPR stores and ranks these memories. More »
Luciano Marraffini, among the first scientists to plumb the workings of the CRISPR-Cas system, is promoted to associate professor
Luciano Marraffini is exploring an immune response used by bacteria to defend against viruses. His work is mainly focused on understanding the basic biology and evolution of microorganisms, but it also has implications for the development of gene-editing technologies. More »
Alex Gitlin and Wenyan Jiang are two of 12 recipients of this prestigious prize, which is given to graduate students at or near the completion of their studies in the biological sciences. Winners are chosen for the quality, originality, and significance of their thesis research. More »
Scientists have discovered an immune-defense mechanism in bacteria that allows these microorganisms to respond to viral infections with remarkable precision. Their findings could have implications for the development of new therapies against infectious diseases. More »
This award, bestowed by the University of Bern, honors Marraffini for his work developing a new approach to fight antibiotic resistance. Marraffini studies CRISPR-Cas systems, which enable some bacteria to acquire immunity against viruses, and is investigating ways to use them to fight off microbial pathogens. More »
Marraffini, who studies the adaptive immune systems, known as CRISPR-Cas systems, found in some bacteria and used in genome editing, has won the Earl and Thressa Stadtman Scholar Award. Meanwhile, Robert Roeder, who investigates the mechanisms that regulate transcription, the process by which genes are copied into RNA, is the recipient of the Herbert Tabor Research Award.
Marraffini, who studies the CRISPR-Cas systems that enable some bacteria to acquire immunity against viruses, is among 32 highly qualified young faculty researchers selected to compete for this national award. More »
For years, researchers have puzzled over conflicting results about the workings of type III CRISPR-Cas systems, a type of immune system found in many species of bacteria. Some data showed that this mechanism would target the virus’s DNA, while other experiments suggested it could only disable a virus once it had started replicating itself. New results suggest both mechanisms play a role.
The enzyme Cas9 is well known for its ability to make precise cuts in a genome. New research reveals a new role for Cas9 in its native bacteria: helping the microbial immune system acquire a memory of an invading virus. More »
By co-opting a system bacteria normally use to defend themselves, researchers targeted and killed off colonies of the antibiotic resistant Staph cells on mouse skin. The treatment left behind the drug-susceptible microbes. More »
Viruses can kill bacteria, or viruses can help the microbes by lending them potentially useful genes. New research shows Staph bacteria have an immune system capable of distinguishing dangerous invaders from potentially beneficial ones. More »
Two Rockefeller University faculty have been awarded the NIH Director’s Transformative Award and three are being given New Innovator Awards.
Experiments in pneumococcal bacteria show how an RNA interference mechanism known as CRISPR can be used to prevent the uptake of genetic material from the environment. Harnessing this mechanism could be a new way to manipulate bacterial evolution in ways that might be medically useful. More »
Rockefeller’s newest faculty member is Luciano Marraffini, a microbiologist who studies how bacterial pathogens modulate the transfer of foreign DNA into their genomes. His work sheds light on how bacteria such as Staphylococcus aureus evolve, including how they gain the ability to resist antibiotic drugs. More »