Tag Archives: Michael O’Donnell

In the News – Newsday – O’Donnell

Researchers at Brookhaven lab, Stony Brook and Rockefeller universities make new discoveries about double helix copying   “In Manhattan, Michael O’Donnell, who heads Rockefeller’s Laboratory of DNA Replication, said the finding will change how students understand DNA replication. ‘It’s a … More »

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Study reveals the architecture of the molecular machine that copies DNA

Study reveals the architecture of the molecular machine that copies DNAUntil now, the exact configuration of the replisome, a block of proteins that unzips the DNA helix and creates two duplicate helices, was unknown. After taking the first complete pictures of it, researchers were surprised to find the complex possesses a counterintuitive architecture, raising new questions about its functions. More »

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Researchers create the first model of the DNA ‘replication fork’

Researchers create the first model of the DNA ‘replication fork’This new tool promises to allow scientists to explore the as-yet-unknown details of how cells unzip the double-stranded DNA molecule and replicate it, a process crucial to life. More »

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Four Rockefeller scientists elected to the National Academy of Sciences

Titia de Lange, Charles D. Gilbert, Michael E. O’Donnell and Jeffrey V. Ravetch, all heads of laboratories at Rockefeller University, have been elected to the U.S. National Academy of Sciences, a private organization of scientists and engineers dedicated to the furtherance of science and its use for the general welfare. More »

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Clearing jams in the copy machinery

Bacteria and humans use a number of tools to direct perhaps the most important function in cells — the accurate copying of DNA during cell division. Now, Rockefeller scientists show that one of these proteins, the beta sliding clamp, serves as a toolbelt, from which the correct proteins are retrieved to enable DNA replication in the face of DNA damage. More »

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