Tag Archives: Michel C. Nussenzweig

New antibody drug continues to show promise for treatment of HIV

New antibody drug continues to show promise for treatment of HIVAntibody therapy may offer an alternative to standard HIV treatments, which require a strict regimen and can cause complications in the long-term. New results from a clinical trial show that the 3BNC117 antibody can significantly delay the virus from rebounding in patients taken off their current medications. More »

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In the News – Los Angeles Times – Nussenzweig

New therapy keeps HIV at bay without daily drug regimen, study says   “Using antibodies against HIV could be part of a ‘kick and kill’ strategy, said study co-author Dr. Michel Nussenzweig — to kick the virus out of its … More »

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Michel C. Nussenzweig honored with the 2016 Robert Koch Award

Michel C. Nussenzweig honored with the 2016 Robert Koch AwardGiven by the Robert Koch Foundation, the annual award is one of Germany’s most prestigious scientific prizes, honoring extraordinary accomplishments in infectious disease research. Nussenzweig will share the €100,000 prize with Alberto Mantovani of Humanitas University for their achievements in immunology. More »

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Antibody therapy opens door to potential new treatment for HIV

Antibody Therapy Opens Door to Potential New Treatment for HIVResearchers are developing an antibody-based drug that may provide a better strategy for long-term control of HIV. New results from a clinical trial suggest that a single dose of a so-called broadly neutralizing antibody enables patients’ immune systems to better fight the virus. More »

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Alex Gitlin and Wenyan Jiang win 2016 Weintraub Graduate Student Awards

Alex Gitlin and Wenyan Jiang win 2016 Weintraub Graduate Student AwardsAlex Gitlin and Wenyan Jiang are two of 12 recipients of this prestigious prize, which is given to graduate students at or near the completion of their studies in the biological sciences. Winners are chosen for the quality, originality, and significance of their thesis research. More »

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Two Rockefeller postdocs recognized by Blavatnik Regional Awards

Two Rockefeller postdocs recognized by Blavatnik Regional Awards

Hani Goodarzi and Ziv Shulman have been named a winner and a finalist, respectively, by the Blavatnik Regional Awards, which honor outstanding postdoctoral scientists in New York, New Jersey, and Connecticut. Goodarzi is a postdoc in Sohail Tavazoie’s lab; Shulman, a former postdoc in Michel Nussenzweig’s lab, has since established his own lab at the Weizmann Institute of Science in Israel.

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In first human study, new antibody therapy shows promise in suppressing HIV infection

In first human study, new antibody therapy shows promise in suppressing HIV infectionIn the first results to emerge from HIV patient trials of a new generation of so-called broadly neutralizing antibodies, Rockefeller University researchers have found the experimental therapy can dramatically reduce the amount of virus present in a patient’s blood. The work, reported this week in Nature, brings fresh optimism to the field of HIV immunotherapy and suggests new strategies for fighting or even preventing HIV infection. More »

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In the News – GlobeAndMail – Nussenzweig

HIV: Latent reservoir of virus in rare immune cells could help develop cure “Research at Rockefeller University suggests that a quiet body of immune cells that do not divide could harbour a reserve of HIV virus, a potential target for … More »

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Imaging studies open a window on how effective antibodies are formed

Imaging studies open a window on how effective antibodies are formedBy imaging the immune response, researchers have observed how two types of immune cells interact with one another during a critical period following infection in order to prepare the best antibodies and establish long-lasting protection. More »

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Antibodies, together with viral ‘inducers,’ found to control HIV in mice

Antibodies, together with viral ‘inducers,’ found to control HIV in miceA new strategy devised by researchers at Rockefeller University harnesses the power of broadly neutralizing antibodies, along with a combination of compounds that induce viral transcription, in order to attack latent reservoirs of HIV-infected cells in an approach termed ‘shock and kill.’ More »

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Discovery helps explain how B cells adapt to their targets

Gitlin-b-cells-thumb2-05052014During an infection, the immune system selects B cells that produce antibodies with a high affinity for the pathogen. New research helps explain the details of how these cells are selected and amplified. More »

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Adjunct faculty member Kayo Inaba receives L’Oréal-UNESCO Women in Science award

Inaba, a member of Michel Nussenzweig’s Laboratory of Molecular Immunology who previously worked in Ralph Steinman’s lab, is known for her work on specialized immune cells called dendritic cells. Inaba is being honored as the Asia-Pacific recipient of the L’Oréal-UNESCO Women in Science award, which supports eminent women in science throughout the world who are working in life and physical sciences. More »

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Potent antibodies neutralize HIV and could offer new therapy, study finds

Rockefeller researchers in Michel Nussenzweig’s Laboratory of Molecular Immunology have found that a newly-discovered class of especially potent antibodies is effective at neutralizing HIV infection in mice for a 60 day period, longer than current antiretroviral drugs which require daily application. The antibodies, which suppressed the virus when used in combination, could one day be given to humans to treat the disease. More »

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Nature online: February 7, 2012

Nature online: February 7, 2012 DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes Ofir Hakim, Wolfgang Resch, Arito Yamane, Isaac Klein, Kyong-Rim Kieffer-Kwon, Mila Jankovic, Thiago Oliveira, Anne Bothmer, Ty C. Voss, Camilo Ansarah-Sobrinho, Ewy Mathe, Genqing … More »


2011 Nobel Prize Ceremony to be webcast live

Tomorrow, the family of Nobel Prize winner Ralph M. Steinman, who died September 30, will accept the Nobel medal and diploma on his behalf from King Carl XVI Gustaf of Sweden. The ceremony will be Webcast live beginning at 10:20 a.m. Eastern Time. A video of the Nobel Prize Award Ceremony will also be available a few days later. More »

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Resident protection

To keep the body safe, the immune system enlists more than one form of protection. Rockefeller University scientists, working in collaboration with researchers at New York University, are learning about an important, but little-known, network of dendritic cells in lymph nodes through innovative, live-action imaging. More »

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Scientists identify broad and potent HIV antibodies that mimic CD4 binding

A new approach gives researchers the ability to isolate single antibodies as well as investigate entire families of highly active antibodies against HIV.
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Michel C. Nussenzweig elected to National Academy of Sciences

Michel C. Nussenzweig, Sherman Fairchild Professor and head of the Laboratory of Molecular Immunology, was elected a member of the National Academy of Sciences at the Academy’s annual meeting today, in recognition of his deep contributions to our understanding of the workings of the innate and adaptive immune systems. More »

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New class of ‘dancing’ dendritic cells derived from blood monocytes

The discovery of a new class of dendritic cells that stem from blood monocytes in mice promises to accelerate research into clinical therapies that use these cells, known to be the sentinels of the immune system. Much research has been done on classical dendritic cells, which are found in the lymph tissues of mice. But these are hard to come by in the case of humans. The new technique may allow the generation of “authentic” dendritic cells from human blood samples, however, which could make it much easier to advance dendritic cell-based vaccines and cancer treatments that are under development now. More »

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Research on killer HIV antibodies provides promising new ideas for vaccine design

By detailing the molecular workings of broadly neutralizing anti-HIV antibodies, found in so-called slow-progressing HIV patients, researchers hope to devise a way to arm those who are not equipped with exceptional immunological firepower. New clues reveal that some anti-HIV antibodies are especially sticky and target a previously unrecognized part of the virus. More »

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