Tag Archives: Michel Nussenzweig

Early intervention with new treatment provides durable control of HIV-like virus in monkeys

Early intervention with new treatment provides durable control of HIV-like virus in monkeysResearchers have found that a new approach to HIV treatment can suppress an HIV-like virus for an extended period in monkeys. The therapy employs antibodies and takes advantage of the immune system’s natural defenses. More »

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Encouraging clinical results for an antibody drug to prevent or treat HIV

Encouraging results for an antibody drug to prevent or treat HIVA drug known as 10-1074, based on a human antibody against HIV, has dramatically reduced virus levels in patients and appeared to prevent infection among those at high risk, according to data from a new clinical trial. More »

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Antibody Combination Puts HIV on the Ropes

Antibody combination puts HIV on the ropesResearchers have shown that a combination of three antibody drugs can completely suppress HIV in infected mice. The antibodies were isolated from a patient whose immune system mounted an unusually effective response against the virus. More »

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New antibody drug continues to show promise for treatment of HIV

New antibody drug continues to show promise for treatment of HIVAntibody therapy may offer an alternative to standard HIV treatments, which require a strict regimen and can cause complications in the long-term. New results from a clinical trial show that the 3BNC117 antibody can significantly delay the virus from rebounding in patients taken off their current medications. More »

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In the News – Los Angeles Times – Nussenzweig

New therapy keeps HIV at bay without daily drug regimen, study says   “Using antibodies against HIV could be part of a ‘kick and kill’ strategy, said study co-author Dr. Michel Nussenzweig — to kick the virus out of its … More »

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Michel C. Nussenzweig honored with the 2016 Robert Koch Award

Michel C. Nussenzweig honored with the 2016 Robert Koch AwardGiven by the Robert Koch Foundation, the annual award is one of Germany’s most prestigious scientific prizes, honoring extraordinary accomplishments in infectious disease research. Nussenzweig will share the €100,000 prize with Alberto Mantovani of Humanitas University for their achievements in immunology. More »

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Antibody therapy opens door to potential new treatment for HIV

Antibody Therapy Opens Door to Potential New Treatment for HIVResearchers are developing an antibody-based drug that may provide a better strategy for long-term control of HIV. New results from a clinical trial suggest that a single dose of a so-called broadly neutralizing antibody enables patients’ immune systems to better fight the virus. More »

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Two Rockefeller postdocs recognized by Blavatnik Regional Awards

Two Rockefeller postdocs recognized by Blavatnik Regional Awards

Hani Goodarzi and Ziv Shulman have been named a winner and a finalist, respectively, by the Blavatnik Regional Awards, which honor outstanding postdoctoral scientists in New York, New Jersey, and Connecticut. Goodarzi is a postdoc in Sohail Tavazoie’s lab; Shulman, a former postdoc in Michel Nussenzweig’s lab, has since established his own lab at the Weizmann Institute of Science in Israel.

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Cell division speeds up as part of antibody selection, study shows

Cell division speeds up as part of antibody selection, study showsIn response to an infection, the immune system refines its defensive proteins, called antibodies, to better target the invader. New research has revealed two mechanisms that favor the selection of B cells capable of producing antibodies finely tuned to target that invader. More »

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Sequential immunizations could be the key to HIV vaccine

Sequential immunizations could be the key to HIV vaccineScientists have thought for some time that multiple immunizations, each tailored to specific stages of the immune response, could be used to generate a special class of HIV-fighting antibodies, so-called broadly neutralizing antibodies. These findings provide the first evidence supporting this approach. More »

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In the News – BBC – Nussenzweig

HIV: new approach against virus “holds promise”   “Michel Nussenzweig of The Rockefeller University told BBC News: ‘This is different to treatment out there already on two counts. First because it comes from a human – so it is natural … More »

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Latent HIV may lurk in ‘quiet’ immune cells, research suggests

Latent HIV may lurk in ‘quiet’ immune cells, research suggestsWhen researchers sequenced and compared sites where the virus had integrated into the genomes of infected CD4 T cells, they found evidence dormant but dangerous HIV was hiding out in cells that had never been copied – not the more abundant cloned cells. More »

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