Tag Archives: MicroRNAs

Small RNAs in blood may reveal heart injury

SmallBy profiling the small RNAs circulating in the blood of healthy people versus those with heart failure, a research team identified three so-called microRNAs with the potential for use as indicators of injury to heart muscle. More »

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MicroRNAs play a role in cocaine addiction

MicroRNAs, short stretches of RNA that silence genes, have already been linked to cancer, heart disease and mental disorders such as schizophrenia. New research by Rockefeller University scientists suggests microRNAs are also involved in regulating the motivation to consume cocaine, a finding that could ultimately lead to new ways of combating addictive diseases in humans. More »

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Genome-wide map shows precisely where microRNAs do their work

MicroRNAs are the newest kid on the genetic block. By regulating the unzipping of genetic information, these tiny molecules have set the scientific world alight with their therapeutic potential and wide-ranging applications. But the question remains: How do they work? By using a technique that molecularly cements proteins to RNAs, Rockefeller scientists have decoded a map of microRNA-messenger RNA interactions in the mouse brain, an advance that holds promise for biology and human disease. More »

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For different species, different functions for embryonic microRNAs

Researchers at The Rockefeller University have discovered that a family of microRNAs that regulates early embryonic development is evolutionarily conserved from fish to amphibians and humans, but its function is not. The findings are a warning: Scientists should not assume that what they learn about microRNAs in animal studies will hold true for people. More »

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New method prevents microRNAs from escaping cells

Since their discovery, microRNAs have been hailed as the stars of the RNA universe, as they have been shown to play a role in countless diseases ranging from cancer to neurological disorders. Now, researchers at Rockefeller University have discovered a better, more reliable way to detect and measure these tiny molecules — work that may lead to improved ways of diagnosing and preventing disease. More »

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Scientists identify a key regulator of DNA mutations

As a general rule, your DNA is not something you want rearranged. But there are exceptions — especially when it comes to fighting infections. Now, two teams of researchers at Rockefeller University independently show how a tiny, recently identified molecule once implicated in cancer can not only help defend against it but also keep invading microbes at bay. More »

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microRNA-203 helps build skin’s protective barrier

It’s a rough world, and exposed skin cells weather conditions harsh enough to mutate DNA. To keep these mutations from spreading, evolution has found a way to keep these cells from proliferating. In a series of elegant experiments, Rockefeller University researchers have now discovered evolution’s solution: a tiny strand of RNA. But the research’s implications go deeper, and may also suggest how healthy cells elsewhere in the body can turn cancerous. More »

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A global view: Researchers build microRNA atlas

Rockefeller University scientists have created a comprehensive microRNA catalog that encompasses more than 250 cell and tissue samples across 26 organ systems as part of a global effort to clarify the role of microRNAs in development and in various diseases, particularly cancer. More »

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MicroRNA works with Ago2 protein to regulate blood cell development

A protein, but not its unique “slicer” component, maintains levels of and executes the function of a key biological regulator within cells, two processes that ultimately control the early development of blood cells. More »

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Brain cells need microRNA to survive

New research from Rockefeller University shows that neurons that cannot produce microRNAs, tiny single strands of RNA that regulate the expression of genes, slowly die in a manner similar to what is seen in such human neurodegenerative disorders as Alzheimer’s and Parkinson’s diseases. More »

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Plant ‘vaccines’ may combat viruses in crops

Plants possess several innate mechanisms to resist viruses, but many viruses are able to overcome these barriers. A new strategy developed by Rockefeller University researchers turns a plant regulatory pathway into an effective defense against infection. More »

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Viral gene hijacks small RNA pathway as a counter-attack strategy

Every day plants are battling for survival against tiny viruses invading their cells. Small RNAs are a major part of the plant’s immune system, but viruses have devised counter-attack molecules that disable this line of defense. Research from Nam-Hai Chua’s laboratory has found a new mechanism for how a viral molecule causes the breakdown of the plant’s defense system. More »

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MicroRNAs linked to mammalian skin development

Since their discovery, microRNAs have been shown to play a role in the development of many organisms, but not mammals. This week, Rockefeller scientists announce that they have found and characterized over one hundred microRNAs in the outer layer and hair follicles of mouse skin. These microRNAs, tiny chunks of RNA that bind to longer segments in order to turn off the production of proteins, are key to the mice’s ability to develop hair follicles and oil glands, the scientists say. More »

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Size doesn’t matter

Rockefeller scientists show that microRNAs play an essential role in many development processes, including cell survival, in the fruit fly embryo. More »

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