Tag Archives: molecular and cell biology
Scientists have discovered a potential new target for the treatment of leukemia that potentially could augment the activity of BET inhibitors, drugs currently in clinical trials. These therapies act on histones, DNA’s packaging proteins, to reset gene regulatory programs that go awry in cancer.
Researchers have determined how a specific protein regulates the brain’s response to cocaine. Their findings provide fresh insights into the neurobiology of addiction, and could lead to the development of better interventions and treatments.
Researchers have described how two proteins work together to guide the assembly of important structural elements known as microtubules within the cell. This discovery helps explain how cells prepare to use these filaments. More »
One important aspect of the internal time-keeping system continues to perplex scientists: its complex response to temperature, which can shift the clock forward or backward, but cannot change its 24-hour period. New experiments help explain how this is possible. More »
Two chemical signals, acetylcholine and glutamate, were known to act as part of the negative reward system that fuels craving, but it wasn’t clear how this happened. In new experiments, researchers have learned that one of these neurotransmitters, acetylcholine, regulates the other, glutamate, to reinforce nicotine dependence. More »
Scientists have gained new insight into the formation of the spindle, which is the molecular machine that divides up genetic material prior to cell division. Their work focuses on the motor protein, kinesin-5, which helps to organize the spindle’s filaments. More »
The nuclear pore complex, a gate into and out of the nucleus, is capable of an impressive feat: allowing large molecules to pass through, both selectively and quickly. Researchers have now identified the molecular mechanism that makes this possible. More »