Tag Archives: Nathaniel Heintz

A possible explanation for why male mice tolerate stress better than females

A possible explanation for why male mice tolerate stress better than femalesRockefeller scientists have described a molecular mechanism that may explain in part why anxiety levels vary between the sexes. The research team identified a molecule that halts the action of a stress-inducing hormone—but it only does so in male mice. More »

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Nathaniel Heintz and Stanislas Leibler elected to the National Academy of Sciences

Nathanial Heintz and Stanislas Leibler elected to the National Academy of SciencesHeintz, who studies the inner workings of the mammalian brain, and Leibler, who explores questions related to how simple genetic and biochemical networks function, are among the new members and foreign associates to be inducted into the Academy. With Heintz and Leibler’s election, Rockefeller now boasts 37 members or foreign associates of the National Academy of Sciences among its current faculty.

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Study reveals new mechanism in nicotine addiction

Study reveals new mechanism in nicotine addictionTwo chemical signals, acetylcholine and glutamate, were known to act as part of the negative reward system that fuels craving, but it wasn’t clear how this happened. In new experiments, researchers have learned that one of these neurotransmitters, acetylcholine, regulates the other, glutamate, to reinforce nicotine dependence. More »

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Newly discovered brain cells explain a prosocial effect of oxytocin

Newly discovered brain cells explain a prosocial effect of oxytocinWhen activated by the ‘love hormone’ oxytocin, a class of star-shaped neurons in the brain’s cortex encourages female mice to take an interest in males, but only when the females are in heat. More »

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Loss of epigenetic regulators causes mental retardation

New findings, published in recent issues of Neuron and Science, indicate that malfunction of a protein complex that normally suppresses gene activation causes mental retardation in mice and humans and may even play a role in promoting susceptibility to drug addiction. More »

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Scientists identify DNA that regulates antibody production

When foreign invaders trip the immune system’s alarm, antibodies need to be specially sculpted to attack them head on. New research now shows that gene segments called enhancers control the reshuffling of antibody genes that makes such a precise and coordinated attack possible. More »

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New nucleotide could revolutionize epigenetics

Genes alone cannot explain the vast differences in the complexity of life. Scientists have found that what makes a worm and a human so much different isn’t the amount of DNA they carry, which is about the same, but rather the dynamic regulation of those genes by nongenetic factors: epigenetics. New research at The Rockefeller University has now uncovered a novel system of epigenetic regulation, one that adds a new nucleotide to the mammalian DNA code. More »

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Gene linked to anxious behavior in mice

Mice and men are different in many ways, of course, especially when it comes to the psychological. But new research linking a gene in mice to anxious behavior raises the prospect that we get some anxiety disorders from a piece of DNA we share with the little mammals. The gene, Lynx2, alters neurotransmission in parts of the mouse brain associated with anxiety. The same parts are associated with anxiety in humans. More »

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Breakthrough in cell-type analysis offers new way to study development and disease

It’s sometimes said that disease does not discriminate, but that’s not true. Many diseases are very particular about the types of cells they attack, laying waste to one population while sparing its nearly identical neighbors for no apparent reason. New research from The Rockefeller University for the first time enables scientists to carefully study the biomolecular differences among types of cells in order to learn what makes some susceptible to attack and others resistant. More »

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Three Rockefeller scientists elected AAAS fellows

Arleen Auerbach, Cori Bargmann and Nathaniel Heintz are new fellows of the world’s largest general scientific society. More »

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GenSAT (Gene Expression Nervous System Atlas) Project announced

For scientists studying the brain, this week’s Nature announces a remarkable new map describing previously uncharted territory, plus the means of exploring the new horizons for themselves. Rockefeller University scientists led by Nat Heintz, Ph.D. and Mary Beth Hatten, Ph.D. are well under way on a genetic atlas of the mammalian brain that provides unprecedented access to central nervous system regions, cell classes and pathways. More »

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Mutated Gene Causes Death of Nerves in Brain

A gene responsible for the degeneration and death of certain nerve cells in the brain has been cloned, yielding information that may be useful for further studies of such neurodegenerative diseases as Alzheimer’s and Parkinson’s, investigators from the Howard Hughes Medical Institute at The Rockefeller University and from The Johns Hopkins School of Medicine report in the Aug. 21 Nature. More »

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