Tag Archives: nuclear pore complex

Researchers shed new light on RNA’s journey out of a cell’s nucleus

Researchers shed new light on RNA’s journey out of a cell’s nucleusTo make proteins, cells must export RNA from their carefully guarded nuclei. Researchers have determined the structure of one important component of the restrictive gate through which this cargo must pass, with implications for understanding disease. More »

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Parasites reveal how evolution has molded an ancient nuclear structure

Parasites reveal how evolution has molded an ancient nuclear structureThe architecture of the nuclear pore complex is similar in humans and yeast, suggesting that it had been established over a billion years ago. But new research in a simple parasite, the trypanosome, indicates that it has actually been evolving steadily. More »

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New findings help explain how molecules are speedily transported into and out of the cell’s nucleus

New findings help explain how molecules are speedily transported into and out of the cell's nucleusThe nuclear pore complex, a gate into and out of the nucleus, is capable of an impressive feat: allowing large molecules to pass through, both selectively and quickly. Researchers have now identified the molecular mechanism that makes this possible. More »

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Research reveals key interaction that opens the channel into the cell’s nucleus

Research reveals key interaction that opens the channel into the cell’s nucleusScientists have uncovered crucial steps in the dynamic dance that dilates and constricts the nuclear pore complex. Their ongoing work has shown this elaborate portal to and from the cell’s nucleus is much more than the inert structure it was once thought to be. More »

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New technique reveals a role for histones in cell division

New technique reveals a role for histones in cell divisionResearchers have found that key aspects of cell division, such as the formation of the support structure for the envelope that surrounds the nucleus, depend on the presence of DNA-organizing proteins known as histones. More »

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Polarized microscopy technique shows new details of how proteins are arranged

A key component of the nuclear pore complex — a Y-shaped cluster of proteins that helps determine what gets in and what stays out of a cell’s nucleus — was first photographed and modeled at Rockefeller in 2009. But fundamental questions about how the structures were aligned in relation to the rest of the 30-protein complex remained. Researchers at Rockefeller University have now developed a new technique that uses polarized light microscopy to help answer questions about the proteins’ orientation. More »

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“Promiscuous” protein interactions found in the nuclear pore complex

The NPC is the only way in or out of a cell’s nucleus. It plays a key role in cellular metabolism and signaling, and any malfunction in these pores can have lethal consequences. Now new research reveals further insights into the design of this evolutionarily ancient and little-understood transport machinery. The findings suggest that the nuclear pore complex takes on different formations to carry out its function. More »

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New research supports model for nuclear pore complex

The pores that control what passes in and out of the cell nucleus play a crucial role in the cell’s metabolism and signaling. Defects in structure and function of these gatekeepers, known as nuclear pore complexes, can have lethal consequences. New research reveals secrets about what may be a key design feature of these structures, a flexibility enabling the import and export of large molecules. More »

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Research suggests core nuclear pore elements shared by all eukaryotes

About 1.7 billion years ago, the cell nucleus burst onto the scene, sequestering the cell’s genetic material inside a protective inner membrane and setting the stage for the evolution of increasingly sophisticated creatures from yeast, say, to plants and human beings. Now research shows that one of the most basic design principles of this new eukaryotic life-form — the gatekeeper to the cell nucleus known as the nuclear pore complex — is largely shared across even the most distantly related eukaryotes. More »

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Research identifies 3D structure of key nuclear pore building block

New research into the molecular machine that filters all information traveling in or out of the cell nucleus contributes to an unfolding picture of cellular evolution that shows a common architecture for the nuclear pore complex (NPC) and the vehicles that transport material between different parts of the cell. Scientists have for the first time glimpsed in three dimensions the subcomplex of the NPC that is its key building block. More »

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Molecular machine turns packaged messenger RNA into a linear transcript

The nuclear pore complex is the only way in or out of the cell nucleus. This assembly also plays a key role in assuring the quality of the genetic information that passes through it. New research shows how one of the pore’s proteins magnetically couples with another molecule to form a machine that helps unpack messenger RNA. More »

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Researchers develop a device that mimics one of nature’s key transport machines

A cell’s nuclear pore complex controls transport of materials from one side to the other. Now, by trying to recreate the structure, scientists have gained a broader understanding of how it works. More »

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Structural study backs new model for the nuclear pore complex

Inside the cell nucleus, DNA is transcribed into RNA that then leaves the nucleus and binds to the cell’s ribosomes, where it is translated into proteins. But in order to get to the ribosome, the RNA must pass through a relatively large, complicated and little-understood structure called the nuclear pore complex. Researchers at The Rockefeller University have a new model for the gatekeeper to the nucleus and have discovered the crystal structure of a protein pair that backs it up. More »

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New model of a nuclear pore complex is based on crystal structure of its key component

In the second nuclear pore study to come out of Rockefeller University in as many months, researchers have determined the crystal structure of one of the pore’s main components. Using that shape as their base, they propose an overall structure for the circular pore: rings of alternating protein complexes that fit together like two sides of a zipper. More »

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Multi-lab collaboration yields first detailed map of nuclear pore complex

The pores that lead into a cell’s nucleus play an incredibly important role in the cell’s metabolism and signaling. Now, Rockefeller University researchers have drafted a protein-by-protein map of the nuclear pore complex’s structure, providing a glimpse into the evolution of the nucleus itself. More »

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Building the nuclear pore piece by piece

Because the nuclear pore is the only way in or out of the nucleus, the cell is in dire straits when the pore malfunctions, as in forms of leukemia where nuclear pore complex proteins are mutated. Two new structural renderings of nuclear pore complex proteins, however, created in the Nobel Prize-winning lab that has worked for nearly 40 years on understanding how proteins are transported within cells, are beginning to shed light on this puzzling assembly. More »

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“Crucial evolutionary link”: Molecular sculptor may have molded simple ancient bacterial cells into modern, highly structured cells

A team of researchers led by Rockefeller University’s Michael P. Rout, Ph.D., have discovered a possible crucial evolutionary link between the simple cells that make up bacteria and the more complex cells that comprise animal and plant cells, including those of humans. More »

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Rockefeller researchers characterize yeast nuclear pore complex

Researchers from The Rockefeller University and the University of Alberta in Canada have obtained the first comprehensive inventory of the protein components of the nuclear pore complex (NPC), an essential cellular structure that regulates transport between the nucleus and the cytoplasm. More »

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