Tag Archives: Obesity

Sweet tooth? Flies have it too—and new research explains how they know what to eat and when to stop

Sweet tooth? Flies have it too—and new research explains how they know what to eat and when to stopIn studying the eating behavior of fruit flies, scientists have discovered a set of throat neurons that regulate food intake based on how hungry the flies are and whether they’ve had enough sugar. A similar neural circuit may exist in vertebrates, like us. More »

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Jeffrey Friedman receives the 2016 Harrington Prize for Innovation in Medicine

Jeffrey Friedman receives the 2016 Harrington Prize for Innovation in MedicineThe award, given by the American Society for Clinical Investigation and the Harrington Discovery Institute, honors those who advance science with achievements notable for innovation, creativity, and potential for clinical application. Friedman is being recognized for his discovery of leptin. More »

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Obesity researcher and former hospital physician-in-chief Jules Hirsch dies

Obesity researcher and former hospital physician-in-chief Jules Hirsch diesHirsch, an early leader in the study of human metabolism, was best known for his work on a landmark study that offered an explanation for why people who lose weight tend to regain it over time. He died at the age of 88. More »

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Physician scientist, interested in obesity-related disease, to join faculty

Physician scientist, interested in obesity-related disease, to join facultyPaul Cohen, a molecular biologist and cardiologist, is returning to Rockefeller where he did his graduate work. In his new lab, Cohen will study the molecular origins of obesity-related metabolic disease with the goal of developing treatments. More »

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In the News – HuffPostSci – Friedman

The good news and the bad news about beating obesity   “We don’t ‘pillory people for being very tall or short,’ [Jeffrey] Friedman said, so it makes no sense to blame obese people for being that way–or for obese people … More »

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Obesity researcher wins Keio Medical Science Prize

Jeffery Friedman shares the 14th Keio Medical Science Prize, awarded annually to researchers for outstanding achievements in the fields of life sciences and medicine, for the “discovery of leptin and the study of its physiological functions.” More »

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Newly identified cells make fat

By using a mouse that lacks fat cells and observing the growth of fat after injections of different kinds of immature cells, Rockefeller University scientists have discovered an important fat precursor cell that may in time explain how changes in the numbers of fat cells might increase and lead to obesity. The scientists’ finding could also have implications for understanding how fat cells affect conditions such as diabetes and cardiovascular disease. More »

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Sex hormone signaling helps burn calories

Any dieter can tell you: Body weight is a function of how much food you eat and how much energy you use. The trick to maintaining a healthy weight lies in regulating the balance. But new research from Rockefeller University suggests that brain cell receptors linked to sex hormones may play a role in the process by which we maintain that balance. More »

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Obese mice provide clues to natural system that puts brakes on obesity

A gene that gets switched on only in the fat cells of obese mice may be a key to preventing obesity in humans, according to new research at The Rockefeller University in New York City and the Joslin Diabetes Center in Boston. More »

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Obesity not a personal failing, says leptin discoverer Jeffrey Friedman, but a battle against biology

Leptin discoverer Jeffrey M. Friedman, M.D., Ph.D., argues in a “Viewpoint” article in a special obesity issue of the journal Science published Feb. 7 that obesity cannot be easily explained as simply a breakdown in willpower. Genes and environment, explains the Rockefeller University and Howard Hughes Medical Institute researcher, both play important roles in determining a person’s body weight. More »

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Leptin “Replacement Therapy” Study in Obese Women Begins

The weight-regulating hormone leptin will be given to obese women in a new study at The Rockefeller University Hospital in New York City to test the effects of the treatment on weight loss. More »

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Resistance to Leptin Contributes to Obesity

Insensitivity to the protein leptin, which helps the body regulate its fat stores, contributes to obesity in mice according to the first formal study of leptin intolerance, report scientists in the Aug. 5 Proceedings of the National Academy of Sciences. The findings also provide clues about leptin’s action in the nervous system and may help to explain some forms of obesity that affect humans, including more than 50 million overweight adult Americans, the researchers note. More »

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Leptin Helps Body Regulate Fat, Links to Diet

Leptin, a protein produced by fat, appears to play an important role in how the body manages its supply of fat, report scientists in the November Nature Medicine. More »

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Rockefeller Researchers Find Evidence That Weight Change in Humans Affects Metabolism

A team of researchers at The Rockefeller University, led by Dr. Rudolph Leibel, has shown that the human body maintains a stable weight by increasing the number of calories burned when weight is gained, and slowing the rate when weight is lost. Dr. Jules Hirsch, Sherman M. Fairchild Professor and physician-in-chief of the Rockefeller University Hospital, and Dr. Michael Rosenbaum are co-authors of the study, to be published tomorrow in The New England Journal of Medicine. More »

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Rockefeller Researchers Clone Gene for Obesity

Fifty years after the discovery at Rockefeller University that genes are made of DNA, Dr. Jeffrey M. Friedman of the Howard Hughes Medical Institute at Rockefeller University and a team of Rockefeller researchers has cloned the first recessive obesity gene in mice and its human homologue, opening a new era for the understanding and, potentially, the treatment of obesity. More »

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