Tag Archives: Paul Greengard

In the News – Today – Flajolet

Alzheimer’s was ‘abstract’ until it affected my family   “November is Alzheimer’s Awareness Month, and the Fisher Center at Rockefeller University is on the frontlines of the battle against the disease. Howard Lutnick, who leads the board at the Fisher … More »

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Study offers insight on how a new class of antidepressants works

Study offers insight on how a new class of antidepressants worksThe experimental drugs target brain cells’ ability to respond to the chemical messenger glutamate, however, it has been unclear how they work. The recent discovery of a molecular amplification system helps explain how the drugs alter signaling in particular neurons to achieve an antidepressant effect. More »

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Helen Hobbs will receive the 2015 Pearl Meister Greengard Prize

Helen Hobbs will receive the 2015 Pearl Meister Greengard PrizeHobbs, of the University of Texas Southwestern Medical Center and the Howard Hughes Medical Institute, is being recognized for her work on the genetic determinants of plasma lipoprotein levels and risk for cardiovascular disease. The prize is intended to honor the extraordinary work of established women scientists and to motivate young women considering careers in the sciences. More »

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A newly discovered molecular feedback process may protect the brain against Alzheimer’s

A newly discovered molecular feedback process may protect the brain against Alzheimer’s Researchers have identified within neurons a series of molecular interactions — known as a pathway — that can dampen the production of the Alzheimer’s protein amyloid-β. These results suggest a new route in the search for therapies for this degenerative disease. More »

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New research sheds light on the molecular origins of Parkinson’s disease

New research sheds light on the molecular origins of Parkinson’s diseaseScientists have identified two proteins that appear to have a protective effect in the set of neurons most affected by this degenerative disease. When the activity of these molecules wanes, disease sets in. This discovery suggests new avenues for preventing or treating Parkinson’s. More »

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In the News – WSJ – Greengard

The mind and its mysteries   “‘We do know from my own work on depression that there seems to be several different parts of the brain involved [in creativity]. Different parts of the brain are all speaking to each other. … More »

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Pearl Meister Greengard Prize to be awarded to pioneering RNA researcher Joan Steitz

A prestigious Rockefeller University award for exceptional women scientists recognizes a pioneer in the field of RNA biology whose discoveries involved patients with a variety of autoimmune diseases. Steitz will receive the award from National Geographic Explorer in Residence Sylvia Earle at a ceremony in Rockefeller’s Caspary Auditorium on November 29. More »

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2011 Pearl Meister Greengard Prize to be awarded to McGill University memory researcher

Brenda Milner, a pioneer in the field of cognitive neuroscience whose discoveries revolutionized the understanding of memory, will be awarded the 2011 Pearl Meister Greengard Prize from The Rockefeller University.
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Anti-inflammatory drugs reduce effectiveness of SSRI antidepressants

Scientists have shown that anti-inflammatory drugs, which include ibuprofen, aspirin and naproxen, reduce the effectiveness of the most widely used class of antidepressant medications, the selective serotonin reuptake inhibitors, or SSRIs, often prescribed for depression and obsessive-compulsive and anxiety disorders. More »

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Molecule that spurs cell’s recycling center may help Alzheimer’s patients

A molecule that activates the cell’s natural recycling program may flush away the protein fragments that accumulate and form senile plaques in Alzheimer’s disease. New research suggests that stimulating this activity, either through drugs or natural processes, may improve the quality of life for people with diseases caused by built-up proteins in the brain. More »

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2010 Pearl Meister Greengard Prize goes to two pioneers of cancer genetics

Janet Davison Rowley and Mary-Claire King, pioneering cancer geneticists, are the recipients of the 2010 Pearl Meister Greengard Prize awarded by The Rockefeller University. Established by Nobel Prize winner Paul Greengard and his wife, sculptor Ursula von Rydingsvard, the prize honors women who have made extraordinary contributions to biomedical science, a group that historically has not received appropriate recognition and acclaim. More »

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Paul Greengard receives Karolinska Institutet’s Bicentennial Gold Medal

The gold medal is the highest award conferred by the Karolinska Institutet, one of the world’s leading medical universities, during its 200th anniversary celebrations. The medal recognizes the work of an individual not permanently located at the Karolinska Institutet, who has contributed to and has achieved acknowledged eminence in the university’s activities. More »

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Scientists identify protein that spurs formation of Alzheimer’s plaques

Rockefeller researchers report that the cancer drug Gleevec reduces Alzheimer’s plaques in a mouse model of the disease by binding to a molecule called gamma-secretase activating protein, or GSAP. By knocking out the gene that produces GSAP, the researchers reduced the primary component of senile plaques. They say that the development of compounds that work like Gleevec and target GSAP could revolutionize the treatment of this disease. More »

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MicroRNAs play a role in cocaine addiction

MicroRNAs, short stretches of RNA that silence genes, have already been linked to cancer, heart disease and mental disorders such as schizophrenia. New research by Rockefeller University scientists suggests microRNAs are also involved in regulating the motivation to consume cocaine, a finding that could ultimately lead to new ways of combating addictive diseases in humans. More »

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Alzheimer’s brain protein may provide target for treating mental retardation

Reducing the level of β-amyloid, a protein found in the brains of patients with Alzheimer’s disease and Down syndrome, may improve the cognitive abilities of children with Down syndrome. The new study by Rockefeller University scientists may provide a model for developing new anti-amyloid drugs. More »

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Scientists identify potential new target for schizophrenia drugs

A protein that boosts the signaling power of a receptor involved in relaying messages between brain cells may provide a new target for the development of treatments for schizophrenia and Parkinson’s disease. More »

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Leslie Vosshall, Paul Greengard win Dart/NYU biotech awards

Rockefeller scientists receive honors for their contributions to next-generation insect repellents and drugs to treat neurological diseases. More »

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Mouse model reveals a cause of ADHD

New research in a mouse model of attention deficit/hyperactivity disorder suggests that the root of the psychiatric disorder might be the over-activity of a protein that regulates the brain’s reward-motivation system. The work suggests a path toward new treatments for symptoms including inattentiveness, over-activity and impulsivity. More »

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Loss of epigenetic regulators causes mental retardation

New findings, published in recent issues of Neuron and Science, indicate that malfunction of a protein complex that normally suppresses gene activation causes mental retardation in mice and humans and may even play a role in promoting susceptibility to drug addiction. More »

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2009 Pearl Meister Greengard Prize goes to pioneering geneticist

The 2009 Pearl Meister Greengard Prize recognizes Suzanne Cory, a world-renowned geneticist and pioneering scientific leader. The first woman to serve as director of Australia’s prestigious Walter and Eliza Hall Institute, she has been an influential force in shaping science policy in her nation. More »

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