Tag Archives: programmed cell death

A newly discovered way for cells to die

A newly discovered way for cells to dieIn studying how worms develop from larvae into adults, scientists have discovered a previously unknown process in which cells are programmed to die. The findings might have implications for understanding some diseases, including neurodegenerative disorders. More »

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Imaging studies reveal order in programmed cell death

In order to thrive, the human body orchestrates a mass suicide of about 10 billion potentially dangerous cells a day. New research takes a closer look at programmed cell death — called apoptosis — and finds order in this process, once thought to be an erratically timed, sudden collapse. More »

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New cell death pathway involved in sperm development

Good swimmers, like healthy sperm, are sleek and light. They shed extra pounds, shape their body and even shave their legs to move efficiently and fast. Sperm also remove excess baggage to function optimally, and caspases, proteins involved in apoptosis, or programmed cell death, facilitate this process. New research from Rockefeller University and the Howard Hughes Medical Institute uncovers a new pathway that regulates caspase activity in Drosophila sperm, a finding that represents a new and promising drug target for therapeutic purposes. More »

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For dying cells, timing is everything

Conventional wisdom suggests that cells are at all times balanced precariously between life and death, with proteins that could kill the cell poised to strike at a moment’s notice. While this is certainly true in some cases, new research from Rockefeller University shows that it is not universal, and that several layers of regulation control cell death. More »

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Researcher discover new cell death program

Though caspases are the accepted executioners of the cell world, new research shows that they may not be the only ones. By following the life, and death, of one cell, Rockefeller University researchers discover a new type of cell death. More »

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Trash talk: Molecular conversations trigger cell suicide in yeast

For cells, like people, relationships are based on good communication. In yeast cells, however, scientists have shown that communication between certain molecules involved in gene regulation can trigger the cell’s suicide program, suggesting that molecular “crosstalk” may be an important mechanism by which cells respond to adverse events like cancer. More »

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Sperm cells shaped by natural cell suicide mechanism

Since discovering that body cells actively commit suicide over 35 years ago, scientists have come to learn that this natural process, called programmed cell death, occurs throughout human tissues, millions of times a day, to eliminate potentially harmful cells, such as those behind cancer. More »

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Researchers Solve Killer Protein’s “Crime”

A killer protein named Reaper. A protective protein in bits and pieces. And a dead cell. This is the scene of one of the body’s most perfect crimes: programmed cell death. This vital process occurs throughout life as a means to, among other purposes, eliminate potentially cancerous cells. More »

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Cells on the Verge of Suicide

A developing cell in the human body sits on the edge of death. Proteins called Grim, Reaper and Hid stand poised, ready to unleash other toxic proteins. Only if a protein messenger from another cell arrives in time to call off the killing, will the cell then mature into any one of the various types of body cells, such as skin, liver and brain. More »

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Researchers Shed Light on How Cells Commit Suicide

A team of researchers led by Associate Professor David Cowburn,Ph.D., has determined the three-dimensional structure of a moleculethat regulates programmed cell death, a critical process importantfor many diseases, including cancer, heart disease and autoimmunity.The structure, reported in the March 5 issue of the journal Cell,provides a model for developing compounds to switch cell suicideon or off to treat these diseases. More »

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Mutated Gene Causes Death of Nerves in Brain

A gene responsible for the degeneration and death of certain nerve cells in the brain has been cloned, yielding information that may be useful for further studies of such neurodegenerative diseases as Alzheimer’s and Parkinson’s, investigators from the Howard Hughes Medical Institute at The Rockefeller University and from The Johns Hopkins School of Medicine report in the Aug. 21 Nature. More »

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