Tag Archives: Ralph M. Steinman

Rockefeller creates Cohn-Steinman Professorship to honor discoverers of dendritic cells

The family of the late Ralph Steinman, who died in September three days before winning the Nobel Prize, will donate much of the proceeds from the award to establish the Cohn-Steinman Professorship at Rockefeller. Combined with other donations, the professorship will create an enduring memorial to Steinman and his mentor and collaborator, Zanvil Cohn. More »

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2011 Nobel Prize Ceremony to be webcast live

Tomorrow, the family of Nobel Prize winner Ralph M. Steinman, who died September 30, will accept the Nobel medal and diploma on his behalf from King Carl XVI Gustaf of Sweden. The ceremony will be Webcast live beginning at 10:20 a.m. Eastern Time. A video of the Nobel Prize Award Ceremony will also be available a few days later. More »

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Resident protection

To keep the body safe, the immune system enlists more than one form of protection. Rockefeller University scientists, working in collaboration with researchers at New York University, are learning about an important, but little-known, network of dendritic cells in lymph nodes through innovative, live-action imaging. More »

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Rockefeller University scientist Ralph Steinman, honored today with Nobel Prize for discovery of dendritic cells, dies at 68

Rockefeller University cell biologist Ralph M. Steinman, who discovered the immune system’s sentinel dendritic cells and demonstrated that science can fruitfully harness the power of these cells and other components of the immune system to curb infections and other communicable diseases, is this year’s recipient of the Nobel Prize in Physiology or Medicine, the Nobel Foundation in Stockholm, Sweden, announced today. He shares half the prize with Bruce A. Beutler and Jules A. Hoffmann. More »

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Michel C. Nussenzweig elected to National Academy of Sciences

Michel C. Nussenzweig, Sherman Fairchild Professor and head of the Laboratory of Molecular Immunology, was elected a member of the National Academy of Sciences at the Academy’s annual meeting today, in recognition of his deep contributions to our understanding of the workings of the innate and adaptive immune systems. More »

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New class of ‘dancing’ dendritic cells derived from blood monocytes

The discovery of a new class of dendritic cells that stem from blood monocytes in mice promises to accelerate research into clinical therapies that use these cells, known to be the sentinels of the immune system. Much research has been done on classical dendritic cells, which are found in the lymph tissues of mice. But these are hard to come by in the case of humans. The new technique may allow the generation of “authentic” dendritic cells from human blood samples, however, which could make it much easier to advance dendritic cell-based vaccines and cancer treatments that are under development now. More »

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New HIV vaccine trial first to target dendritic cells

HIV has been able to outmaneuver every vaccine that’s been tried on the virus since it was first discovered in 1981. But no vaccine has yet to directly employ what is arguably the most powerful weapon the human immune system, the dendritic cells that orchestrate the body’s response to infection. Now that’s about to change. Researchers at Rockefeller University, where dendritic cells were discovered in 1973, are building on decades worth of research to launch a novel vaccine trial in hopes of mustering an immune response strong enough to defeat the deadly virus. It’s the first clinical trial of a dendritic cell based vaccine against infection, and researchers hope it will mark a turning point in the battle against AIDS. More »

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Ralph M. Steinman receives 2010 Heineken Prize for Medicine

Rockefeller immunologist Ralph M. Steinman receives Dutch prize for his discovery of the dendritic cell and its role in the immune response. More »

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First evidence that the brain’s native dendritic cells can muster an immune response

Since their initial discovery in 1973, dendritic cells, the sentinels of the immune system, have turned up in a number of places other than the immune organs. They stand guard in the heart, for instance, and in 2008, the first population native to the brain was identified. New research shows that dendritic cells are not only present in the brain, but active, too. They confront foreign substances and seem to form a barrier between healthy and stricken brain tissue following a stroke. More »

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Ralph Steinman awarded 2009 Albany Medical Center Prize

Head of Rockefeller University’s Laboratory of Cellular Physiology and Immunology and the discoverer of dendritic cells, Ralph M. Steinman is one of three recipients of this year’s Albany Medical Center Prize, at $500,000 the largest scientific prize in the country. More »

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Dendritic cells as a new player in arteries and heart valves

Discovered by Ralph M. Steinman in 1973, dendritic cells have been implicated in early immune responses such as graft rejection, resistance to tumors and autoimmune diseases. New research shows that these relatively rare immune cells may play a role in heart disease as well. Experiments show that dendritic cells project their dendrites into the bloodstream, where they can capture foreign invaders and turn them over to T cells for destruction. More »

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DNA vaccines get a boost from dendritic cells

DNA vaccines show promise for fighting off HIV, SARS, influenza and other diseases, but aren’t yet potent enough for human use. Adding dendritic cells to the mix may provide the oomph they need. More »

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Experimental HIV vaccine gets a boost from ’70s-era discovery

A long-neglected molecule called poly-IC may see new life as a vaccine adjuvant. New research shows that, in combination with a novel AIDS vaccine, it helps mice maintain their immunity. More »

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Rockefeller immunologist receives Lasker Award for Basic Medical Research

This year’s Albert Lasker Award for Basic Medical Research honors Rockefeller University’s Ralph M. Steinman, who discovered dendritic cells, the preeminent component of the immune system that initiates and regulates the body’s response to foreign antigens. More »

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Dendritic cells stimulate production of immune-repressing T cells

Regulatory T cells, which are important for suppressing immune response, could potentially be exploited for different immune therapies. A new study takes researchers a step closer to this goal, showing that the suppressor cells are generated by dendritic cells — cells already known for their ability to direct immune system response. More »

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Subset of dendritic cells could be used to fight infection

Despite the prevalence of the parasitic disease leishmaniasis in tropical countries, there is currently no vaccine to prevent its transmission. But a new study shows that targeting a specific set of immune cells may result in a substantial boost in immune response. More »

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Dendritic cells may be key to reversing diabetes

Type 1 diabetes occurs when the body’s own immune system assaults the cells responsible for producing insulin. Now, researchers studying the immune system’s dendritic cells have found a way to stop the destruction and help revive and maintain the population of insulin-producing β cells in mice, a discovery that could lead to a lasting cure. More »

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Dendritic cell receptor may be the key to an HIV vaccine

Recent attempts to develop a vaccine have elicited only limited action from two immune system cells, helper T cells and killer T cells. But Rockefeller University scientists working on a new approach have evidence that targeting a third group of immune cells, dendritic cells, may be even more effective than they’d previously believed. Now new research shows that the dendritic cells’ DEC-205 receptor may be the key to making it work. More »

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By targeting dendritic cells, HIV and malarial vaccines outperform competitors

Although DNA-based vaccines are often in the limelight, scientists at Rockefeller University are developing a completely different approach to inducing immunity, one that directs a vaccine straight to the immune cells of living animals and, eventually, humans. More »

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Rockefeller University vaccine researchers selected for grant from Foundation for NIH

A team of researchers led by Rockefeller University immunologist Ralph M. Steinman, M.D., has been selected for a grant offer from the Foundation for the NIH (FNIH) of $14 million to support the design of novel vaccines that stimulate multiple components of the body’s immune response, including those that have been difficult to target with existing vaccine approaches. More »

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