Tag Archives: Robert B. Darnell

Robert Darnell named president of New York Genome Center

Darnell will direct all aspects of the NYGC, including its scientific and research activities, and the recruitment and development of a world-class scientific team in genomic research and medicine. Founded in 2010, the NYGC will be one of the largest genomics research facilities in North America, integrating sequencing, bioinformatics and data management. More »

Tags: , , ,

Five Rockefeller scientists receive high risk-high reward NIH grants

Two Rockefeller University faculty have been awarded the NIH Director’s Transformative Award and three are being given New Innovator Awards.
More »

Tags: , , , , , , , , ,

Robert B. Darnell and Victor Wilson named 2010 AAAS Fellows

Rockefeller University scientists Robert B. Darnell and Victor Wilson have been awarded the distinction of AAAS Fellow. Election as a fellow is an honor bestowed upon AAAS members by their peers. More »

Tags: , ,

Two Rockefeller scientists elected to Institute of Medicine

Rockefeller University scientists Robert B. Darnell, head of the Laboratory of Molecular Neuro-oncology, and Titia de Lange, head of the Laboratory of Cell Biology and Genetics, have been elected to the Institute of Medicine, the health and medicine branch of the National Academy of Sciences. More »

Tags: , , ,

Genome-wide map shows precisely where microRNAs do their work

MicroRNAs are the newest kid on the genetic block. By regulating the unzipping of genetic information, these tiny molecules have set the scientific world alight with their therapeutic potential and wide-ranging applications. But the question remains: How do they work? By using a technique that molecularly cements proteins to RNAs, Rockefeller scientists have decoded a map of microRNA-messenger RNA interactions in the mouse brain, an advance that holds promise for biology and human disease. More »

Tags: ,

Scientists discover master regulator of motor neuron firing

When the Human Genome Project was complete, DNA bowed out of the limelight and gave way to RNA as a major player in genetic regulation. New findings that reveal the master architect behind a functioning motor neuron not only mirror this ideological shift but further point to the increasingly indisputable role of RNA as the molecule behind biological complexity. More »

Tags: ,

New method provides panoramic view of protein-RNA interactions in living cells

The postgenomic era has taught us a big one: That the measure of human complexity has less to do with how many genes we have as it does with how we process them. Now, Rockefeller University scientists offer, for the first time, a genome-wide view — from the first chromosome to the last — of how differences in RNA can explain how a worm and a human can each have 25,000 genes yet be so different. More »

Tags: , ,

RNA map gives first comprehensive understanding of alternative splicing

Though scientists have begun to appreciate how alternative splicing adds a layer of complexity to brain processes that enable us to think and learn, exactly how alternative splicing is regulated during these processes — and in some cases is uncontrolled (or dysregulated) to cause disease — has remained elusive. A new map, however, provides the first comprehensive understanding of how alternative splicing works throughout the genome. The results have implications for a better understanding of such brain functions as learning and memory, neurological diseases and cancer biology. More »

Tags: ,

A single protein is crucial to memory formation, scientists show

New findings show that a single protein called Nova is responsible for regulating the quality of the information that is processed in the spaces between brain cells. More »

Tags: ,

Researchers describe new technique for cataloging RNA targets in rare brain disease

RNA, often thought of as merely the chemical messenger that helps decode DNA’s genetic instructions for making proteins, can itself play a crucial role in regulating protein expression. Not surprisingly, this regulation occurs through proteins that bind to RNA. All cells in the body, especially nerve cells in the brain, use and regulate RNA in an exquisite fashion. More »

Tags: , ,

“Vanishing Breed” of Researchers Recognized by HHMI

Robert B. Darnell, M.D., Ph.D., whose bench-to-bedside studies at Rockefeller University have uncovered new insights about how the brain normally works and about tumor immunity, is one of the 12 physician-scientists selected for a new Howard Hughes Medical Institute (HHMI) program spotlighting the value of relating basic research discoveries to improving medical therapy. More »

Tags:

Researchers Uncover Molecular Basis of Second Leading Cause of Mental Retardation

Scientists at last may have determined how mental retardation develops in people with fragile X syndrome, a condition caused by the inherited loss of an essential protein, termed the fragile X mental retardation protein (FMRP). The new research demonstrates that FMRP controls the fate of several specific proteins in brain cells and thus may explain why the absence of this single protein can cause the range of physical, cognitive and behavioral abnormalities characteristic of fragile X syndrome. More »

Tags: , ,

Rockefeller Researchers Discover Possible Trigger for “Killer T Cells” To Attack

How do “killer T cells” know when to attack virus-infected and cancerous cells, and when to retreat? The answer possibly has been provided by Rockefeller University research to be published in the Nov. issue of Nature Immunology. More »

Tags: , ,

Rockefeller University researchers identify protein that regulates RNA in nerve tissue

Protein may play a key role in nervous system function Rockefeller University researchers have identified a protein that is responsible for regulating RNA splicing in nerve cells, a process essential for the development and operation of complex nervous systems, such as those found in mammals, including humans. The protein, called Nova-1, is the first splicing factor specific to one kind of tissue to be found in mammals. More »

Tags: , ,

Rockefeller University researchers shed light on brain disorder

A rare but devastating neurological disorder may be caused partly by immune-system cells that are spurred into action against tumors elsewhere in the body and eventually attack the brain, Rockefeller University researchers report. The scientists also found that the neurological damage from these cells, called cytotoxic T lymphocytes (CTLs), might be lessened by giving patients an immunosupressant drug. More »

Tags: , ,

Rockefeller Researchers Show First Evidence for Naturally Occurring Tumor Immunity in Humans

A team of researchers from The Rockefeller University have now shown for the first time that humans are able to develop naturally occurring immunity to cancer. The study, reported in the November issue of Nature Medicine, provides support for the recent efforts to treat cancer patients by activating their immune response in a manner that would lead to tumor immunity, a treatment called immunotherapy. An understanding of naturally occurring tumor immunity is important for the development of better strategies to treat cancer. More »

Tags: , , ,