Tag Archives: Roderick MacKinnon

MacKinnon lab charts the anatomy of three molecular channels

MacKinnon lab charts the anatomy of three molecular channelsBy determining the three-dimensional structures of these molecules down to the level of atoms, the researchers have unlocked key details as to how they function in the body. More »

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New molecular map reveals how cells spew out potassium

New molecular map reveals how cells spew out potassiumResearchers have determined for the first time the complete structure of an ion channel known as BK, or “big potassium.” This molecular map offers new insights on how BK works and may aid in the development of treatments for diseases in which it malfunctions. More »

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Newly described ion channel structure reveals how excited neurons settle down

The long anticipated structure of an ion channel reveals how excited neurons settle downThe channel, Slo2.2, helps restore neurons’ internal electrical state, and so prevents them from firing at too high a frequency for too long, which has the potential to damage the cells. With the new information about Slo2.2’s configuration, researchers can better understand how it accomplishes this. More »

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Atomic-level view provides new insight into translation of touch into nerve signals

Atomic-Level View Provides New Insight into Translation of Touch into Nerve SignalsAn ion channel responsible for dampening potentially painful sensations uses a never-before-seen mechanism to shut itself off: A lipid from the nearby cellular membrane protrudes into the channel, blocking it. More »

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Rendering of ion channel suggests how neurons fire

When a nerve cell fires, membrane proteins known as voltage-dependent ion channels open to allow the flow of charged atoms called ions across the cell membrane. The opening of voltage-dependent ion channels is mediated by voltage sensors, which contain charged amino acids that move within the membrane in response to voltage changes. Now, new research from Rockefeller University reveals how these charged amino acids are stabilized on voltage sensor paddles and how they move within the lipid membrane. More »

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Ion flow through membrane channels is dictated by particle size

Ion channels are small passageways that control the movement of electrically charged particles across a cell’s membrane. Now, new research reveals the thermodynamics behind how one type of ion channel determines which particles to let through. More »

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Phospholipids in the cell membrane help regulate ion channels

Though the cell membrane is a protective barrier, it also plays a role in letting some foreign material in — via ion channels that dot the cell’s surface. Now new research from the Nobel Prize-winning laboratory that first solved the atomic structure of several such channels shows that their function is controlled in part by a complex interaction between a channel’s voltage sensor and the cell membrane immediately adjacent to it. More »

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Nobel Prize honors Rockefeller University scientist Roderick MacKinnon for revealing process of electrical signaling in humans and other living organisms

Rockefeller University Professor Roderick MacKinnon, M.D., a biophysicist and X-ray crystallographer whose exquisitely detailed portraits of a class of proteins explain the generation of nerve impulses — the electrical activity that underlies all movement, sensation and thought — is honored this year with the Nobel Prize in Chemistry, the Nobel Foundation in Stockholm, Sweden announced today. MacKinnon, who also is an investigator at the Howard Hughes Medical Institute, shares the prize with Peter Agre, M.D., at Johns Hopkins University School of Medicine. More »

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MacKinnon lab’s newest picture tells action potential story

Scientists studying the tiny devices — called voltage-dependent ion channels — that are responsible for all nerve and muscle signals in living organisms for 50 years have been working like a bunch of blindfolded art critics. More »

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Another Transmembrane Protein Structure Solved by Rockefeller Scientists

“Why did nature come up with such a structural plan?” ask Rockefeller University professor Roderick MacKinnon and colleagues in their Jan. 17 Nature cover article describing the three-dimensional structure of a type of chloride channel called the ClC. More »

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Roderick MacKinnon elected to U.S. National Academy of Sciences

Professor Roderick MacKinnon, head of the Laboratory of Molecular Neurobiology and Biophysics and an investigator at the Howard Hughes Medical Institute, was elected to membership in the U.S. National Academy of Sciences (NAS) at the Academy’s 137th meeting on Tues., May 2. MacKinnon studies the functional and structural architecture of ion channel proteins, molecules that govern the electrical potential of membranes throughout nature, thereby generating nerve impulses and controlling muscle contraction, cardiac rhythm and hormone secretion. More »

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Rockefeller Researcher Roderick MacKinnon Receives 1999 Lasker Award

Rockefeller University Professor Roderick MacKinnon, M.D., has been named a recipient of the 1999 Albert Lasker Basic Medical Research Award, the nation’s most distinguished honor for outstanding contributions to basic and clinical medical research. More »

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