Tag Archives: Sidney Strickland

Potential Alzheimer’s drug prevents abnormal blood clots in the brain

Potential Alzheimer’s drug prevents abnormal blood clots in the brainThe brains of Alzheimer’s mice treated with the compound RU-505 showed less inflammation and better blood flow than those of untreated mice. The treated mice also performed better on memory tests. More »

Tags: , , , , , ,

Therapy for fearsome brain disease could target blood

Alzheimer’s disease isn’t just about twisted brain cells, but also the blood vessels that feed those neurons. Previous research at Rockefeller University showed that the most common element of telltale plaque deposits in Alzheimer’s brains leads to the formation of tougher blood clots, which could choke off oxygen flow to neurons. The new research shows how these clots are formed, suggesting a target for a drug that might prevent them. More »

Tags: , , ,

Problematic blood clotting contributes to Alzheimer’s disease

Alzheimer’s disease isn’t just about twisted brain cells. It’s also about the blood vessels that feed those neurons. New research at Rockefeller University has shown how the most common element of the plaque deposits found outside the brain cells of Alzheimer’s patients interacts with a blood clotting agent and causes clots to form faster and become harder to break down. The scientists suggest new drugs that would target this association could potentially treat what is increasingly recognized as a crucial element of the disease, the vascular component. More »

Tags: , , ,

Discovery could help scientists stop the ‘death cascade’ of neurons after a stroke

Millions of stroke victims suffer permanent brain damage every year because neurons start spitting out the neurotransmitter glutamate when they are deprived of oxygen. It doesn’t take long before the brain cells drown in their own salts. Now a team of scientists at Rockefeller University have for the first time found a way to slow cell death by blocking a specific subunit of the glutamate receptor, a method that avoids the devastating side effects of disrupting the receptor as a whole. More »

Tags: , ,

Stress response in the brain relies on a blood-thinning protein

Our ability to learn from stressful situations allows us to try to avoid them in the future. New research by Rockefeller University scientists shows that a protein called tPA in the hippocampus — a region of the brain responsible for memory, learning and fear — plays an essential role in this learned fear response and could be involved in depression. More »

Tags: ,

Blood-clotting protein may be new target for Alzheimer’s drugs

By decreasing fibrin in the brains of mice with Alzheimer’s, researchers found they were also able to decrease inflammation — a known correlate of cognitive impairment. More »

Tags: , ,

Neurons in the brain change shape when stressed

Rockefeller University scientists are inching closer to understanding how long-term stress can change an area of the brain responsible for learning and memory. In a finding that may have implications for the treatment of post traumatic stress disorder and severe depression, they report that an animal’s response to chronic stress is at least partially dependent on an enzyme called tissue plasminogen activator, or tPA. More »

Tags: , ,

Blocking alcohol’s impact on brain cells

Rockefeller University scientists, in experiments with mice, have discovered a protein that regulates the seizures induced by ethanol withdrawal. The protein, called tissue plasminogen activator, or tPA, is the same factor that dissolves the blood clots that can trigger heart attacks and strokes. More »

Tags: , ,