Tag Archives: stem cells

Zika infection may affect adult brain cells, suggesting risk may not be limited to pregnant women

Zika infection may affect adult brain cells, suggesting risk may not be limited to pregnant womenA new study shows for the first time that the Zika virus can infect the adult brain in regions that are vital to learning and memory. The findings suggest that the virus could have more subtle effects than have been recognized, perhaps contributing to such conditions as long-term memory loss or depression. More »

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New faculty member investigates how cells respond to mechanical forces

Gregory Alushin will relocate his lab to Rockefeller early next yearBiophysicist Gregory Alushin studies how cells use their structural filaments to respond to forces generated as the cells move about, or by movements in the surrounding tissue. He will relocate his lab to Rockefeller early next year. More »

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New insights into muscular dystrophy point to potential treatment avenues

New insights into muscular dystrophy point to potential treatment avenuesCertain stem cells in our bodies have the potential to turn into either fat or muscle. Experiments in mice suggest prospective drugs that manipulate these cells’ fate could make it possible to relieve many of the symptoms of muscular dystrophy. More »

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In the News – Mental Floss – Brivanlou

What Iran May Be Able to Teach Us About Stem Cells   “Now, there are opportunities for collaborations with non-Iranian scientists—which has Ali Brivanlou, who leads the Stem Cell Biology and Molecular Embryology lab at The Rockefeller University, intrigued about … More »

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New research clarifies how stem cells get activated to produce new hair—and what happens when their regenerative powers wear out

New research clarifies how stem cells get activated to produce new hair—and what happens when their regenerative powers wear outStem cells residing in hair follicles are held in an inactive state for long periods of time. A new study shows that these quiescent periods are essential for maintaining the cells’ rejuvenating activity over time, and clarifies the mechanisms that bring the cells in and out of quiescence. More »

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Study identifies signals that make early stem cells

Study identifies signals that make early stem cellsWhere and when do stem cells first appear during development? Researchers investigated this question by examining how cells organize as the hair follicle first appears in mouse embryos. They uncovered signaling pathways that may provide insights into some skin cancers. More »

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Odd histone helps suppress jumping genes in stem cells, study says

Odd histone helps suppress jumping genes in stem cells, study saysThe histone variant H3.3 appears to help keep certain genetic elements called retrotransponsons in place in the genome, preventing potentially harmful mutations in mouse embryonic stem cells, researchers have found. This discovery reveals a basic mechanism for epigenetics, or the control of inherited traits through means other than DNA. More »

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Discovery links shift in metabolism to stem cell renewal

Discovery links shift in metabolism to stem cell renewalNew research links stem cell metabolism with those cells’ decision to pick a fate or renew themselves. In experiments, exposure to a key metabolite called alpha-ketoglutarate enhanced the renewal of mouse embryonic stem cells. More »

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Stem cell progeny tell their parents when to turn on

Hsu-follicle-vertical-05052014During an infection, the immune system selects B cells that produce antibodies with a high affinity for the pathogen. New research helps explain the details of how these cells are selected and amplified. More »

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Cancer stem cells identified, offering new drug targets

Stem cell researchers at Rockefeller University have identified stem cells of squamous cell skin carcinoma, the second most common cancer in the world, and their molecular signature. The researchers find differences between cancer stem cells and healthy skin stem cells, which provide invaluable diagnostic marker and suggests the possibility to specifically target the root of cancer while leaving normal cells unaffected. More »

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Elaine Fuchs awarded 2011 Albany Medical Center Prize

Rockefeller scientist is recognized for her contributions toward realizing the vast potential of stem cells to treat and reverse disease. More »

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Elaine Fuchs to receive Passano Award

World leader in skin biology and its human genetic disorders is honored for landmark contributions to skin biology and its disorders, including genetic syndromes, stem cells and cancers. More »

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New genetic technique probes the cause of skin cell differentiation in mammals

Most complex genetic experiments have been done in simple model organisms like flies and worms, because they’re easier to work with. But new research at Rockefeller University has applied the technique of RNA interference to probe the DNA of our fellow mammal, the mouse. In the process, the researchers are uncovering a deeper understanding of cell differentiation in early development, and hope to apply the results to cancer research. More »

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Research shows when stem cell descendants lose their versatility

The precocious progenitors of every cell in the body — stem cells — have commitment issues. They must remain unattached to maintain the versatility they need to respond to injuries, regenerate tissues and do their other jobs. New research defines the point at which a developing lineage of hair follicle stem cells do settle down, however, and commit to their mission to grow new hair. The findings also reflect a new concept in stem cell biology: that the newly specialized cells send signals back to the stem cells from which they originated, regulating their behavior. More »

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Gene identified that prevents stem cells from turning cancerous

Stem cells have tremendous regenerative power, but their potency can also be lethal. Now researchers have identified a gene that prevents stem cells from turning into tumors in mice by regulating the process of programmed cell death, or apoptosis. The work is the first to show that interfering with the programmed death of stem cells can have fatal consequences. More »

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Elaine Fuchs to receive 2010 L’Oréal-UNESCO prize for women scientists

Elaine Fuchs — one of five women scientists around the world selected by the L’Oréal-UNESCO For Women in Science partnership to receive the 2010 L’Oréal-UNESCO Awards in the Life Sciences — is honored for her contributions to our knowledge of skin biology and skin stem cells. More »

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Two proteins enable skin cells to regenerate

Skin cells that have lost their luster flake off and are replaced by new ones that push their way up to the surface. In new research that further dissects how stem cells specialize into tissue cells, scientists now show how these new skin cells arise — work that may one day hold promise for burn victims. More »

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Epigenetic mark guides stem cells toward their destiny

Not all stem cells are completely blank slates. Some, known as adult stem cells, have already partially embraced their fates. Researchers now highlight the interactions between genetic and epigenetic regulators in skin stem cells and how these interactions change as stem cells begin the process of specialization. The findings may also lead to new therapies for prematurely born infants who have not yet fully formed the skin. More »

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Rockefeller University president applauds new U.S. policy on stem cells

Today’s executive order making federal money once again available for research on human embryonic stem cells will accelerate biomedical research and hopefully bring us closer to cures for some of our most devastating diseases, says Rockefeller University president Paul Nurse. More »

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Stem cells in hair follicles point to general model of organ regeneration

Most people consider hair as a purely cosmetic part of their lives. To others, it may help uncover one of nature’s best-kept secrets: the body’s ability to regenerate organs. New research now gets to the root of the problem, revealing that the hair follicle uses a two-step mechanism to activate its stem cells and order them to divide. The mechanism provides insights into how stem cells may be organized in other body tissues to support organ regeneration. More »

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