Tag Archives: stem cells

Stem cell progeny tell their parents when to turn on

Hsu-follicle-vertical-05052014During an infection, the immune system selects B cells that produce antibodies with a high affinity for the pathogen. New research helps explain the details of how these cells are selected and amplified. More »

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Cancer stem cells identified, offering new drug targets

Stem cell researchers at Rockefeller University have identified stem cells of squamous cell skin carcinoma, the second most common cancer in the world, and their molecular signature. The researchers find differences between cancer stem cells and healthy skin stem cells, which provide invaluable diagnostic marker and suggests the possibility to specifically target the root of cancer while leaving normal cells unaffected. More »

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Elaine Fuchs awarded 2011 Albany Medical Center Prize

Rockefeller scientist is recognized for her contributions toward realizing the vast potential of stem cells to treat and reverse disease. More »

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Elaine Fuchs to receive Passano Award

World leader in skin biology and its human genetic disorders is honored for landmark contributions to skin biology and its disorders, including genetic syndromes, stem cells and cancers. More »

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New genetic technique probes the cause of skin cell differentiation in mammals

Most complex genetic experiments have been done in simple model organisms like flies and worms, because they’re easier to work with. But new research at Rockefeller University has applied the technique of RNA interference to probe the DNA of our fellow mammal, the mouse. In the process, the researchers are uncovering a deeper understanding of cell differentiation in early development, and hope to apply the results to cancer research. More »

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Research shows when stem cell descendants lose their versatility

The precocious progenitors of every cell in the body — stem cells — have commitment issues. They must remain unattached to maintain the versatility they need to respond to injuries, regenerate tissues and do their other jobs. New research defines the point at which a developing lineage of hair follicle stem cells do settle down, however, and commit to their mission to grow new hair. The findings also reflect a new concept in stem cell biology: that the newly specialized cells send signals back to the stem cells from which they originated, regulating their behavior. More »

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Gene identified that prevents stem cells from turning cancerous

Stem cells have tremendous regenerative power, but their potency can also be lethal. Now researchers have identified a gene that prevents stem cells from turning into tumors in mice by regulating the process of programmed cell death, or apoptosis. The work is the first to show that interfering with the programmed death of stem cells can have fatal consequences. More »

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Elaine Fuchs to receive 2010 L’Oréal-UNESCO prize for women scientists

Elaine Fuchs — one of five women scientists around the world selected by the L’Oréal-UNESCO For Women in Science partnership to receive the 2010 L’Oréal-UNESCO Awards in the Life Sciences — is honored for her contributions to our knowledge of skin biology and skin stem cells. More »

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Two proteins enable skin cells to regenerate

Skin cells that have lost their luster flake off and are replaced by new ones that push their way up to the surface. In new research that further dissects how stem cells specialize into tissue cells, scientists now show how these new skin cells arise — work that may one day hold promise for burn victims. More »

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Epigenetic mark guides stem cells toward their destiny

Not all stem cells are completely blank slates. Some, known as adult stem cells, have already partially embraced their fates. Researchers now highlight the interactions between genetic and epigenetic regulators in skin stem cells and how these interactions change as stem cells begin the process of specialization. The findings may also lead to new therapies for prematurely born infants who have not yet fully formed the skin. More »

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Rockefeller University president applauds new U.S. policy on stem cells

Today’s executive order making federal money once again available for research on human embryonic stem cells will accelerate biomedical research and hopefully bring us closer to cures for some of our most devastating diseases, says Rockefeller University president Paul Nurse. More »

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Stem cells in hair follicles point to general model of organ regeneration

Most people consider hair as a purely cosmetic part of their lives. To others, it may help uncover one of nature’s best-kept secrets: the body’s ability to regenerate organs. New research now gets to the root of the problem, revealing that the hair follicle uses a two-step mechanism to activate its stem cells and order them to divide. The mechanism provides insights into how stem cells may be organized in other body tissues to support organ regeneration. More »

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Protein that controls hair growth also keeps stem cells slumbering

By combining clinical and scientific research, scientists at Rockefeller University reveal that a protein involved in hair growth also keeps the skin’s stem cells from proliferating. This research raises questions about what stem cells need in order to maintain their ability to regenerate tissues — questions that may be key in developing treatments for patients with thinning hair. More »

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Rockefeller to receive state money for stem cell research

The first state grants from a multi-year $600 million initiative overseen by the newly created Empire State Stem Cell Board will fund new shared equipment and services to support research in more than a dozen Rockefeller University labs working to understand the mechanisms of stem cells More »

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Chemical cues turn embryonic stem cells into cerebellar neurons

vIn order to differentiate and specialize, stem cells require very specific environmental cues in a very specific order, and scientists have so far been unable to prod them to go through each of the necessary steps. But now, for the first time, a study in mice shows that embryonic stem cells implanted in the brain appear to develop into fully differentiated granule neurons, the most plentiful neuron in the cerebellum. More »

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Scientists clone mice from adult skin stem cells

The potential of stem cells has so far gone largely untapped, despite the great promise that stem cells hold. But new research from Rockefeller University now shows that adult stem cells taken from skin can be used to clone mice using a procedure called nuclear transfer. More »

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A master repressor protein, Tcf3, holds stem cells back until the time is right

Tcf proteins are well known for their role in a pathway called Wnt that regulates communication between cells. But new research shows that these proteins also function when Wnt signaling is low or absent, and suggests that Tcf3 maintains multipotent skin stem cells throughout development and holds them back from differentiating in adults. Then, when those cells receive a Wnt signal, Tcf3 switches its role, and coaxes the cells to choose a fate. More »

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Study of hair follicles leads researchers to a key stem cell protein

With all the excitement over what stem cells can become, a few basic questions tend to be overlooked: Where do they come from? And how do they survive? Now Rockefeller University’s Elaine Fuchs has come a step closer to addressing the issue, showing that in hair follicles, the protein Lhx2 acts as a molecular brake to regulate the switch between stem cell maintenance and activation. More »

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Nine Rockefeller labs to receive Stem Cell Initiative grants

The Tri-Institutional Stem Cell Initiative, comprising three leading New York City biomedical research institutions — Memorial Sloan-Kettering Cancer Center, The Rockefeller University and Weill Medical College of Cornell University — has announced the first wave of stem cell research projects to be funded through a $50 million gift from The Starr Foundation. More »

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Human stem cells can contribute to a developing mouse embryo, despite evolutionary differences

A new line of human embryonic stem cells, created using private funds, has been coaxed to grow inside a developing mouse embryo, giving scientists the unique opportunity to observe as the undifferentiated cells replicate and specialize. The results offer a groundbreaking means of both elucidating the beginning of human embryonic development and serving as a starting point from which to understand their potential therapeutic secrets of human embryonic stem cells. More »

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