Tag Archives: structural and chemical biology

New study resolves the structure of the human protein that causes cystic fibrosis

New study resolves the structure of the human protein that causes cystic fibrosis In order to better understand how genetic mutations give rise to cystic fibrosis, researchers need to map the protein responsible for the disorder. The new structure has led to new insights on how this molecular channel functions. More »

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MacKinnon lab charts the anatomy of three molecular channels

MacKinnon lab charts the anatomy of three molecular channelsBy determining the three-dimensional structures of these molecules down to the level of atoms, the researchers have unlocked key details as to how they function in the body. More »

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New molecular map reveals how cells spew out potassium

New molecular map reveals how cells spew out potassiumResearchers have determined for the first time the complete structure of an ion channel known as BK, or “big potassium.” This molecular map offers new insights on how BK works and may aid in the development of treatments for diseases in which it malfunctions. More »

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First structural map of the cystic fibrosis protein sheds light on how mutations cause disease

First structural map of the cystic fibrosis protein sheds light on how mutations cause diseaseA map that shows the arrangement of atoms within the cystic fibrosis protein will help researchers better understand how specific mutations cause disease. Ultimately, this knowledge may reveal potential targets for new drugs. More »

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