Tag Archives: Tarun Kapoor

Friction harnessed by proteins helps organize cell division

Researchers have found that the fastener proteins that organize cell division can harness the movement around them to do their work. Movement of filaments within the structure responsible for cell division can cause some of these proteins to shuffle along the path of least resistance and into position. More »

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Studies describe key role for a protein in cell division

New research shows how one protein, PRC1, acts in the penultimate stage of cell division to help form the architectural structures, called central spindles, needed before the cell can split in two. More »

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Measuring the strength needed to move chromosomes

The tiny meiotic spindle, which teases apart chromosomes during cell division, plays a crucial role in maintaining an accurate replication of the genome. Researchers have used biochemical experiments to study it extensively, but until now, no one has been able to examine its mechanical properties. Rockefeller University professor Tarun Kapoor and colleagues have devised a system to probe these microscopic spindles and have used it for the first time to measure the structure’s stiffness and deformability. More »

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Rockefeller announces tenure appointments of two faculty

Rockefeller University president Paul Nurse has announced the tenure promotion of two faculty members: Tarun Kapoor, a researcher in cell division and head of Rockefeller’s Laboratory of Chemistry and Cell Biology, and Michael P. Rout, head of the Laboratory of Cellular and Structural Biology, which focuses on the nuclear pore complex. Both were promoted from associate professor to professor. More »

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Dividing cells find their middle by following a protein ‘contour map’

Self-organization keeps schools of fish, flocks of birds and colonies of termites in sync. It’s also, according to new research, the way cells regulate the final stage of cell division. Scientists at Rockefeller University have shown that a protein-chemistry-based contour map, which helps individual proteins locate the center of their cell without direction from a “master organizer,” is key to ensuring accurate division during mitosis. More »

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‘Hitchhiking’ chromosomes yield new theory of cell division

From the moment the cell was discovered, scientists have been dissecting the methodical, multi-step process by which they duplicate themselves. This week, Rockefeller researchers studying one component of this process — how a cell’s chromosomes move in preparation for division — announce a discovery that overturns current cell-division theory. More »

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Rockefeller researchers identify new role for key protein that regulates separation of DNA in dividing cells

Rockefeller University scientists have revealed a new function of a key component of the mechanism that cells use to accurately separate chromosomes when they divide. Disruptions in this process can cause diseases such as cancer. More »

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Rockefeller researchers identify how protein linked to cancer correct cells when they divide

A protein, which has been linked to tumor formation when it is overproduced, in normal amounts actually helps correct errors during cell division that can lead to cancer and other diseases, according to new research by scientists at Rockefeller University in the March issue of Nature Cell Biology. More »

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Rockefeller researchers identify new mechanism that ensures accurate partitioning of genetic material in dividing cells

Every minute, the human body replaces 300 million of its dying cells with new ones through the vital biological process known as cell division. When dividing and multiplying, a “parent” cell must segregate with exquisite precision each of its 46 chromosomes so that two “daughter” cells inherit all of its genetic information. More »

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