Tag Archives: Titia de Lange
Cori Bargmann, Titia de Lange win inaugural Breakthrough Prizes worth $3 million
Two Rockefeller University scientists are among 11 winners of the first annual Breakthrough Prize in Life Sciences, an award established by six tech entrepreneurs dedicated to advancing breakthrough research. At $3 million each, the prizes are worth more than twice the amount of the Nobel. They were created to recognize excellence in research aimed at curing intractable diseases and extended human life.
Administered by a new non-profit organization, the Breakthrough Prize in Life Sciences Foundation, the prize is founded by Art Levinson, chairman of the board of Apple and former CEO of Genentech; Sergey Brin, co-founder of Google Inc.; Anne Wojcicki, co-founder of 23andMe; Mark Zuckerberg, founder and CEO of Facebook, and his wife Pricilla Chan; and Yuri Milner, founder of the Russian internet company Mail.ru. More »
Tags: Cori Bargmann, Titia de Lange
Starr collaboration illuminates mysterious pathway to immortality in cancer cells
Tags: cancer, Telomeres, Titia de Lange
Titia de Lange to receive Heineken Prize
De Lange is honored for her work on telomeres, the protective DNA sequences located at the tips of chromosomes which play a crucial role in such processes as ageing and cancer.
Titia de Lange receives 2011 Vilcek Prize in Biomedical Science
Rockefeller researcher is honored for her research on mechanisms that help maintain genome stability. More »
Two Rockefeller scientists elected to Institute of Medicine
Rockefeller University scientists Robert B. Darnell, head of the Laboratory of Molecular Neuro-oncology, and Titia de Lange, head of the Laboratory of Cell Biology and Genetics, have been elected to the Institute of Medicine, the health and medicine branch of the National Academy of Sciences. More »
Rockefeller postdoc named finalist for Blavatnik Awards for Young Scientists
Agnel Sfeir, a postdoctoral fellow in Titia de Lange’s Laboratory of Cell Biology and Genetics, has been named a finalist in the fourth annual Blavatnik Awards for Young Scientists competition, which recognizes the contributions of young scientists and engineers in New York, New Jersey and Connecticut. More »
Titia de Lange receives AACR Clowes Award
Titia de Lange is the 50th annual recipient of the American Association of Cancer Research’s award to an individual with outstanding recent accomplishments in basic cancer research. More »
Titia de Lange awarded grant, named American Cancer Society Research Professor
The head of Rockefeller University’s Laboratory of Cell Biology and Genetics has received a $400,000 grant from the American Cancer Society and has been named an American Cancer Society Research Professor. The five-year grant, which is effective January 1, 2010, will fund de Lange’s continuing research on telomeres, the strings of extra DNA that cap and protect the ends of chromosomes through numerous cycles of cell division. More »
Handle with care: Telomeres resemble DNA fragile sites
Although telomeres are fragile, they don’t have to be handled with care. Researchers at Rockefeller University now show that what keeps our fragile telomeres from falling apart is a protein known as TRF1 that ensures the smooth progression of DNA replication to the end of a chromosome. The work not only shows how telomeres help chromosomes protect their vulnerable ends but also reveals how the genome is made more stable by them. More »
Tags: Telomeres, Titia de Lange
A new role for a critical DNA molecule in the immune system
Researchers find that a molecule that helps repair broken DNA is required for the genetic reshuffling that enables the immune system to adapt to new threats. The finding furthers our understanding of a process that is fundamental to our immune response but can also lead to cancers and other diseases when it falters. More »
Eroded telomeres are behind a rare premature aging syndrome
At a time when the world seems to be age-obsessed, researchers at Rockefeller University reveal the molecular defect behind a rare yet fatal premature aging syndrome, findings that may ultimately help scientists disentangle which genes play a role in the normal aging process from those involved in age-related disease. More »
Mammalian protein plays unexpected role in cell division, and perhaps cancer
In yeast, the protein Tel2 regulates the length of telomeres, DNA sequences that protect the ends of linear chromosomes. But in humans and mice, Tel2 does nothing of the sort. Instead, researchers at Rockefeller University are the first to show that mammalian Tel2 prevents the degradation of a family of six proteins that primarily regulate cell division and proliferation, an unexpected role that may be linked to cancer. More »
Tags: cell division, Telomeres, Titia de Lange
Two proteins found on telomeres control DNA damage response pathways
The shelterin complex, which binds specifically to telomeres, has a built-in mechanism to repress DNA damage response pathways at chromosome ends. More »
Tags: Telomeres, Titia de Lange
De Lange, Nussenzweig elected to American Academy of Arts and Sciences
Rockefeller University faculty will become members of the independent policy and research center devoted to studying complex emerging problems. More »
Living cells prosper without telomeres
In most cells, telomeres are a critical protection against death: If these caps at the ends of chromosomes fail, the cell’s life is cut short. But what’s true for most cells isn’t true for all cells, and a surprising new finding from Rockefeller University shows that cells in the livers of living mice have the remarkable ability to function without telomeres. More »
Tags: Telomeres, Titia de Lange
Evidence of rapid evolution is found at the tips of chromosomes
Humans like to think of themselves at the top of the evolutionary ladder, but new research from Titia de Lange’s lab at Rockefeller University shows that we may have slipped a few rungs in favor of a smaller, fuzzier mammal. While studying the role of a protein called POT1 in telomeres, de Lange’s lab found that mice have evolved ahead, expanding the one gene found in humans into two, each with a distinct function. Their research has important implications for the future of telomere biology. More »
Tags: Telomeres, Titia de Lange
Four Rockefeller scientists elected to the National Academy of Sciences
Titia de Lange, Charles D. Gilbert, Michael E. O’Donnell and Jeffrey V. Ravetch, all heads of laboratories at Rockefeller University, have been elected to the U.S. National Academy of Sciences, a private organization of scientists and engineers dedicated to the furtherance of science and its use for the general welfare. More »
Titia de Lange receives NIH Pioneer Award
The National Insitutes of Health has selected Titia de Lange, who examines how cells respond to DNA damage, to receive up to $500,000 in direct costs per year for five years. The prestigious Pioneer Award, now in its second year, supports groundbreaking, high-risk research that, if successful, will have a significant impact. More »
How Aging Cells Retire
As we grow older, our hair turns gray, our bones grow thin and, among other changes, our telomeres shrink. But, more than markers of the passage of time, telomeres, the tips of chromosomes, may harbor answers to the fundamental mechanisms of aging and cancer. More »
Tags: cell division, Telomeres, Titia de Lange
Newly Identified Protein Caps Chromosomes Ends
A newly isolated protein is a vital part of human telomeres, the shields that guard the ends of chromosomes against damage and destruction. Scientists at Rockefeller University and Memorial Sloan-Kettering Cancer Center report their identification and cloning of the protein in the Dec. 8 Science. More »
Tags: Telomeres, Titia de Lange, TRF
