Tag Archives: Titia de Lange

Research resolves contradiction over protein’s role at telomeres

Research resolves contradiction over protein’s role at telomeresWhen researchers tagged telomeres, protective ends on chromosomes (green and red), of human cells engineered to lack a particular protein, the telomeres did not attach to one another as some previous studies suggested they would. More »

Tags: , , , , , ,

Titia de Lange to receive Canada Gairdner International Award

de Lange is being recognized for her discovery of the mechanisms by which mammalian telomeres are protected from deleterious DNA repair and damage responses. The Gairdner is Canada’s highest scientific award and is considered among the most prestigious international prizes in science. More »

Tags: ,

Cori Bargmann, Titia de Lange win inaugural Breakthrough Prizes worth $3 million

Two Rockefeller University scientists are among 11 winners of the first annual Breakthrough Prize in Life Sciences, an award established by six tech entrepreneurs dedicated to advancing breakthrough research. At $3 million each, the prizes are worth more than twice the amount of the Nobel. They were created to recognize excellence in research aimed at curing intractable diseases and extended human life.

Administered by a new non-profit organization, the Breakthrough Prize in Life Sciences Foundation, the prize is founded by Art Levinson, chairman of the board of Apple and former CEO of Genentech; Sergey Brin, co-founder of Google Inc.; Anne Wojcicki, co-founder of 23andMe; Mark Zuckerberg, founder and CEO of Facebook, and his wife Pricilla Chan; and Yuri Milner, founder of the Russian internet company Mail.ru. More »

Tags: ,

Starr collaboration illuminates mysterious pathway to immortality in cancer cells

A detailed analysis of a large panel of so-called ALT cell lines shows that they frequently undergo chromosomal changes and are impaired in their ability to detect and repair damage in their DNA. The work suggests a mechanism by which 10 to 15 percent of human cancers develop. More »

Tags: , ,

Titia de Lange to receive Heineken Prize

De Lange is honored for her work on telomeres, the protective DNA sequences located at the tips of chromosomes which play a crucial role in such processes as ageing and cancer.

More »

Tags: ,

Titia de Lange receives 2011 Vilcek Prize in Biomedical Science

Rockefeller researcher is honored for her research on mechanisms that help maintain genome stability. More »

Tags: , ,

Two Rockefeller scientists elected to Institute of Medicine

Rockefeller University scientists Robert B. Darnell, head of the Laboratory of Molecular Neuro-oncology, and Titia de Lange, head of the Laboratory of Cell Biology and Genetics, have been elected to the Institute of Medicine, the health and medicine branch of the National Academy of Sciences. More »

Tags: , , ,

Rockefeller postdoc named finalist for Blavatnik Awards for Young Scientists

Agnel Sfeir, a postdoctoral fellow in Titia de Lange’s Laboratory of Cell Biology and Genetics, has been named a finalist in the fourth annual Blavatnik Awards for Young Scientists competition, which recognizes the contributions of young scientists and engineers in New York, New Jersey and Connecticut. More »

Tags: , , , ,

Titia de Lange receives AACR Clowes Award

Titia de Lange is the 50th annual recipient of the American Association of Cancer Research’s award to an individual with outstanding recent accomplishments in basic cancer research. More »

Tags: , , ,

Titia de Lange awarded grant, named American Cancer Society Research Professor

The head of Rockefeller University’s Laboratory of Cell Biology and Genetics has received a $400,000 grant from the American Cancer Society and has been named an American Cancer Society Research Professor. The five-year grant, which is effective January 1, 2010, will fund de Lange’s continuing research on telomeres, the strings of extra DNA that cap and protect the ends of chromosomes through numerous cycles of cell division. More »

Tags: ,

Handle with care: Telomeres resemble DNA fragile sites

Although telomeres are fragile, they don’t have to be handled with care. Researchers at Rockefeller University now show that what keeps our fragile telomeres from falling apart is a protein known as TRF1 that ensures the smooth progression of DNA replication to the end of a chromosome. The work not only shows how telomeres help chromosomes protect their vulnerable ends but also reveals how the genome is made more stable by them. More »

Tags: ,

A new role for a critical DNA molecule in the immune system

Researchers find that a molecule that helps repair broken DNA is required for the genetic reshuffling that enables the immune system to adapt to new threats. The finding furthers our understanding of a process that is fundamental to our immune response but can also lead to cancers and other diseases when it falters. More »

Tags: ,

Eroded telomeres are behind a rare premature aging syndrome

At a time when the world seems to be age-obsessed, researchers at Rockefeller University reveal the molecular defect behind a rare yet fatal premature aging syndrome, findings that may ultimately help scientists disentangle which genes play a role in the normal aging process from those involved in age-related disease. More »

Tags: , ,

Mammalian protein plays unexpected role in cell division, and perhaps cancer

In yeast, the protein Tel2 regulates the length of telomeres, DNA sequences that protect the ends of linear chromosomes. But in humans and mice, Tel2 does nothing of the sort. Instead, researchers at Rockefeller University are the first to show that mammalian Tel2 prevents the degradation of a family of six proteins that primarily regulate cell division and proliferation, an unexpected role that may be linked to cancer. More »

Tags: , ,

Two proteins found on telomeres control DNA damage response pathways

The shelterin complex, which binds specifically to telomeres, has a built-in mechanism to repress DNA damage response pathways at chromosome ends. More »

Tags: ,

De Lange, Nussenzweig elected to American Academy of Arts and Sciences

Rockefeller University faculty will become members of the independent policy and research center devoted to studying complex emerging problems. More »

Tags: , ,

Living cells prosper without telomeres


In most cells, telomeres are a critical protection against death: If these caps at the ends of chromosomes fail, the cell’s life is cut short. But what’s true for most cells isn’t true for all cells, and a surprising new finding from Rockefeller University shows that cells in the livers of living mice have the remarkable ability to function without telomeres. More »

Tags: ,

Evidence of rapid evolution is found at the tips of chromosomes

Humans like to think of themselves at the top of the evolutionary ladder, but new research from Titia de Lange’s lab at Rockefeller University shows that we may have slipped a few rungs in favor of a smaller, fuzzier mammal. While studying the role of a protein called POT1 in telomeres, de Lange’s lab found that mice have evolved ahead, expanding the one gene found in humans into two, each with a distinct function. Their research has important implications for the future of telomere biology. More »

Tags: ,

Four Rockefeller scientists elected to the National Academy of Sciences

Titia de Lange, Charles D. Gilbert, Michael E. O’Donnell and Jeffrey V. Ravetch, all heads of laboratories at Rockefeller University, have been elected to the U.S. National Academy of Sciences, a private organization of scientists and engineers dedicated to the furtherance of science and its use for the general welfare. More »

Tags: , , , ,

Titia de Lange receives NIH Pioneer Award

The National Insitutes of Health has selected Titia de Lange, who examines how cells respond to DNA damage, to receive up to $500,000 in direct costs per year for five years. The prestigious Pioneer Award, now in its second year, supports groundbreaking, high-risk research that, if successful, will have a significant impact. More »

Tags: , ,