Tag Archives: transcription factors

Scientists pinpoint molecule that controls stem cell plasticity by boosting gene expression

Scientists pinpoint molecule that controls stem cell plasticity by boosting gene expressionExperiments placed Sox9 at the crux of a shift in gene expression associated with hair follicle stem cell identity. The molecule first makes stem cell genes accessible so they can become active, then recruits other molecules that promote the expression of these genes in stem cells found at the base of the hair follicle. More »

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New glimpse into early brain development shows how nerve cells move into position

By pinning down how cells in the brain’s cerebellum migrate and differentiate during the first stages of brain development, researchers show that different combinations of regulatory proteins called transcription factors are responsible for driving these changes. More »

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Modular structure enables TRCF protein to both halt transcription and repair DNA

Using x-ray crystallography, Rockefeller scientists have now solved the structure of a protein — called Transcription-Repair Coupling Factor or TRCF — that plays a dual role in DNA transcription repair. The results show that TRCF employs a modular structure which would allow for conformational changes so that TRCF’s recruitment of the repair machinery doesn’t interfere with its interruption of transcription. More »

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Wrong Proteins Targeted in Battle Against Cancer?

Researchers may be looking for novel cancer drugs in the wrong places, says Rockefeller University Professor James E. Darnell Jr., M.D., in an article in this month’s Nature Reviews Cancer. More »

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Tidying Up Transcription Factors

Fifty years ago, in the early days of biology, so little was known about the cell that all of the proteins outside of its nucleus were grouped into one big “cytoplasmic soup.” Now, as the list of known cellular ingredients continues to expand beyond the capacity of any recipe card, two Rockefeller University scientists are taking a step back to ask whether there might be a better way to organize the current thinking about a particularly important class of proteins inherent to all living cells. More »

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