Tag Archives: TRCF

Modular structure enables TRCF protein to both halt transcription and repair DNA

Using x-ray crystallography, Rockefeller scientists have now solved the structure of a protein — called Transcription-Repair Coupling Factor or TRCF — that plays a dual role in DNA transcription repair. The results show that TRCF employs a modular structure which would allow for conformational changes so that TRCF’s recruitment of the repair machinery doesn’t interfere with its interruption of transcription. More »

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